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ProteomicsFusion partners influence cellular and molecular phenotypes of oncogenic BRAF fusions
Fusion genes can be oncogenic drivers in a variety of cancer types and represent potential targets for targeted therapy. The BRAF gene is frequently involved in oncogenic fusions, with fusion frequencies of 0.2-3% throughout different cancers. However, BRAF fusions rarely occur in the same gene conf...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD013461 | Pride
Resistance Crc Fusion partner Organoids Braf Signaling Fusion genes 
Unknownβ2 adrenergic receptor fluorescent protein fusions traffic to the plasma membrane and retain functionality.
Not available
S-EPMC3781101 | biostudies-literature
TranscriptomicsRoles of membrane-Anchoring ARHGAP fusions in peritoneal metastasis of gastric and pancreatic cancer.
Diffuse-type gastric cancer (DGC) frequently metastasizes to the peritoneal cavity and causes malignant ascites. Although recent studies revealed that RHOA mutation and CLDN18-ARHGAP6/26 fusions are a hallmark of DGC, their roles are largely unknown. Here, we report the roles of two novel ARHGAP fus...
ORGANISM(S): Homo sapiens 
2020-12-31 | GSE100627 | GEO
TranscriptomicsPandemic H1N1 Influenza A Directly Induces a Robust and Acute Inflammatory Gene Signature in Primary Human Bronchial Epithelial Cells Downstream of Membrane Fusion
Pandemic H1N1 influenza A (H1N1pdm) elicits stronger pulmonary inflammation than previously circulating seasonal H1N1 influenza A (sH1N1), yet mechanisms of inflammatory activation in respiratory epithelial cells during H1N1pdm infection are unclear. We investigated host responses to H1N1pdm / sH1N...
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-48575 | biostudies-arrayexpress
TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-25827 | biostudies-arrayexpress
GenomicsHomo sapiens
Roles of membrane-Anchoring ARHGAP fusions in peritoneal metastasis of gastric and pancreatic cancer.
PRJNA392318 | ENA
ProteomicsAlternative splicing of Arabidopsis G6PD5 can recruits the NADPH-producing OPPP reactions to the endoplasmic reticulum
Glucose-6-phosphate dehydrogenase is the rate-limiting enzyme of the oxidative pentose-phosphate pathway (OPPP). The OPPP mainly provides NADPH and sugar-phosphate building blocks for anabolic pathways and is present in all eukaryotes. In plant cells, the irreversible part of the OPPP is found in se...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2022-07-11 | PXD035221 | JPOST Repository
UnknownMistic's membrane association and its assistance in overexpression of a human GPCR are independent processes.
Not available
S-EPMC4282410 | biostudies-literature
UnknownCoronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation.
Not available
S-EPMC4019139 | biostudies-literature
UnknownHeat treatment of thioredoxin fusions increases the purity of α-helical transmembrane protein constructs.
Not available
S-EPMC8376418 | biostudies-literature
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