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MetabolomicsFatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids

Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-...

2022-05-31 | MTBLS4709 | MetaboLights
MetabolomicsControlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-24 | MTBLS12437 | MetaboLights
GenomicsPlasma Membrane Integrity Signaling
Plasma Membrane Integrity Signaling
PRJNA701242 | ENA
TranscriptomicsThe Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network
Lipid composition can differ widely among organelles and even between leaflets of a membrane. Lipid homeostasis is critical because disequilibrium can have disease outcomes. Despite their importance, mechanisms maintaining lipid homeostasis remain poorly understood. Here, we establish a model system...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-25 | E-GEOD-39419 | biostudies-arrayexpress
TranscriptomicsPlasma Membrane Integrity Signaling
To understand the transcriptional response of mammalian cells to plasma membrane stress we induced partial loss of plasmid membrane integrity by chemogenetic induction of pore forming proteins (Gasderimin and MLKL) or treatment with the detergent digitonin. We monitored transcription with mRNAseq in...
ORGANISM(S): Mus musculus Homo sapiens 
2021-10-04 | GSE166538 | GEO
UnknownCHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity.
Not available
S-EPMC8350547 | biostudies-literature
GenomicsRIPK3 activation leads to cytokine synthesis that continues after loss of cell membrane integrity
RIPK3 activation leads to cytokine synthesis that continues after loss of cell membrane integrity
PRJNA554367 | ENA
ProteomicsStructure of an essential inner membrane protein-LPS complex identifies a novel anti-microbial peptide
Lipopolysaccharide (LPS) resides in the outer membrane (OM) of Gram-negative bacteria where it is responsible for barrier function and immune modulation. LPS is the target of polymyxins, last-resort antibiotics whose clinical use is threatened by increasing resistance. Steps in LPS biogenesis are ...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2019-05-08 | MSV000083754 | MassIVE
UnknownAnnexin A4 and A6 induce membrane curvature and constriction during cell membrane repair.
Not available
S-EPMC5696365 | biostudies-literature
GenomicsMolecular interplay between peptidoglycan integrity and outer membrane asymmetry in maintaining cell envelope homeostasis
Molecular interplay between peptidoglycan integrity and outer membrane asymmetry in maintaining cell envelope homeostasis
PRJNA1301904 | ENA
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