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MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
ProteomicsErythrocyte Membrane Microdomains
Cholesterol-rich microdomains are membrane dynamic compartments characterized by specific lipid and protein composition and present in all cell types. These assemblies are involved in several biological processes, including infection by intracellular pathogens. This work provides a comprehensive ana...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-05 | MSV000086413 | MassIVE
GenomicsInteraction between TBP and condensing drives the organization and faithful segregation of mitotic chromosomes
Genome/chromosome organization is highly ordered and controls nuclear events. Here, we show that the TATA box-binding protein (TBP) interacts with the Cnd2 kleisin subunit of condensin to mediate interphase and mitotic chromosome organization in fission yeast. TBP recruits condensin onto RNA polymer...
ORGANISM(S): Schizosaccharomyces pombe 
2015-08-12 | E-GEOD-60273 | biostudies-arrayexpress
OtherSystematically Ranking the Tightness of Membrane Association for Peripheral Membrane Proteins.
Data from ProteomeXchange, PXD ID: PXD001246. File: GLY_M11_20140408.mzml. Published as part of Mol Cell Proteomics. 2014 Dec 13 . From the Abstract: {{i}} Large scale quantitative evaluation of the tightness of membrane association for non-transmembrane proteins is important for identifying true p...
ORGANISM(S): Synechococcus_phage_p60_uid14628, Synechococcus_phage_syn5_uid19763, Synechococcus_phage_syn9_uid17541, Synechococcus_phage_s_pm2_uid15223, Synechococcus_phage_s_rsm4_uid39923, Synechocystis_pcc_6803 
GPM32320007112 | GPMDB
Resource Reanalysis 
TranscriptomicsRUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.
RUNX1 is a transcription factor functioning both as an oncogene and a tumor suppressor in breast cancer. RUNX1 alters chromatin structure in cooperation with chromatin modifier and remodeling enzymes. In this study, we examined the relationship between RUNX1-mediated transcription and genome organiz...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-75070 | biostudies-arrayexpress
ProteomicsCFAP418 participates in membrane-associated cellular processes through binding lipids during ciliogenesis
iliopathies and retinal degenerative diseases are heterogeneous groups of genetic diseases. CFAP418 is a causative gene of both diseases, and its sequence is evolutionarily conserved. Here, we employ affinity purification coupled with mass spectrometry and quantitative lipidomic, proteomic, and phos...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-05-05 | MSV000089424 | MassIVE
UnknownStructural insights into the membrane microdomain organization by SPFH family proteins.
Not available
S-EPMC8807802 | biostudies-literature
GenomicsLoss of neuronal 3D chromatin organization causes transcriptional and behavioral deficits related to serotonergic dysfunction [ChIP-seq]
The interior of the neuronal cell nucleus is a highly organized 3-dimensional (3D) structure in which regions of the genome that are millions of bases apart participate in specialized sub-structures with dedicated functions. To investigate neuronal chromatin organization and dynamics in vivo, we gen...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-56809 | biostudies-arrayexpress
GenomicsArchitectural protein subclasses shape 3-D organization of genomes during lineage commitment
Understanding the topological configurations of chromatin can reveal valuable insights into how the genome and epigenome act in concert to control cell fate during development. Here we generate high-resolution architecture maps across seven genomic loci in embryonic stem cells and neural progenitor...
ORGANISM(S): Mus musculus 
2013-05-24 | E-GEOD-36203 | biostudies-arrayexpress
ProteomicsLight-dependent dynamics of phosphorylation of the thylakoid structural protein CURT1B
The regulation of the photosynthetic apparatus in higher plants is highly connected to the organization of the thylakoid membrane into appressed and non-appressed regions. The two photosystems (I and II) are the spatially strongest segregated protein complexes by this thylakoid heterogenous organiza...
ORGANISM(S): Arabidopsis Thaliana 
2019-11-01 | PXD014562 | panorama
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