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TranscriptomicsDetection of circRNA in Drosophila Fly heads and S2 cells using RNA-seq with or without RNaseR tretment
We determined circRNA abundance in fly Heads and S2 cells by generating and analyzing high-throughput RNA-sequencing libraries prepared from rRNA-depleted RNA. In order to determine whether the observed sequencing reads are due to bona fide circRNAs, we pre-treated the RNA with RNAse-R before the rR...
ORGANISM(S): Drosophila melanogaster 
2014-10-14 | E-GEOD-55872 | biostudies-arrayexpress
TranscriptomicsIdentification and characterization of circular RNAs as a new class of putative biomarkers in human blood
Covalently closed circular RNA molecules (circRNAs) have recently emerged as a class of RNA isoforms with widespread and tissue specific expression across animals, oftentimes independent of the corresponding linear mRNAs. circRNAs are remarkably stable and sometimes highly expressed molecules. Here,...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-73570 | biostudies-arrayexpress
TranscriptomicsAnalysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals
Circular RNAs (circRNAs) are a large class of animal RNAs. To investigate possible circRNA functions, it is important to understand circRNA biogenesis. Besides human Alu repeats, sequence features that promote exon circularization are largely unknown. We experimentally identified new circRNAs in C. ...
ORGANISM(S): Caenorhabditis elegans 
2015-01-06 | E-GEOD-63823 | biostudies-arrayexpress
GenomicsThe SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation
The activating E2F-transcription factors are best known for their dependence on the Retinoblastoma protein and their role in cellular proliferation. E2F3 is uniquely amplified in specific human tumours where its expression is inversely correlated with the survival of patients. Here, E2F3 interaction...
ORGANISM(S): Mus musculus 
2011-12-19 | E-GEOD-33791 | biostudies-arrayexpress
Genomics1fcf2848-b51f-450f-a20d-02c6d8156eb7 - samples
Dataset consists of fastq files of Ribo-seq, polyA-RNA and total RNA sequencing of 80 samples (65 DCM cases and 15 controls)
EGAD00001004394 | EGA
GenomicsAnalysis of translatome, truncating mutations, lncRNA, circRNA and microproteins of 80 human DCM cases and controls
The regulation of gene expression in healthy and diseased human tissues is incompletely understood and has primarily been studied on the transcriptional level. Here, we quantify the impact of translation on gene expression and annotate novel translational events in 80 human hearts. These include 65 ...
EGAS00001003263 | EGA
GenomicsDAC for Cardiac Translatomes of 80 Human Samples (65 DCM cases 15 controls)
Data Access Committee EGAC00001001040
EGAC00001001040 | EGA
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