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GenomicsGenome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors (ChIP-Seq)
Inactivating mutations in the MEN1 gene predisposing to the multiple endocrine neoplasia type 1 (MEN1) syndrome can also cause sporadic pancreatic endocrine tumors. MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes that trimethylate histone H3 at lysine 4 (H3K...
ORGANISM(S): Mus musculus 
2012-06-01 | E-GEOD-37774 | biostudies-arrayexpress
TranscriptomicsDifferentially regulated genes in adipocytes derived from Men1-null vs WT mouse embryonic stem cells
MEN1 is a tumor suppressor gene loss of which causes lipoma (fatty tumors under the skin) and many other endocrine and non-endocrine tumors. It's target genes in fat cells (adipocytes) are unknown. Gene expression in adipocytes that were in vitro differentiated from mouse embryonic stem cells (mES...
ORGANISM(S): Mus musculus 
2016-02-03 | E-GEOD-65859 | biostudies-arrayexpress
TranscriptomicsGenome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors
This SuperSeries is composed of the following subset Series: GSE37774: Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors (ChIP-Seq) GSE37775: Genome-wide characterization of menin-dependent H3K4me3 reve...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-37776 | biostudies-arrayexpress
ProteomicsDOT1 Like Histone Lysine Methyltransferase (DOT1L) and Menin 1 (MEN1) interaction proteomics in breast cancer cell nuclei
Estrogen Receptor alpha (ERα) is a ligand-inducible transcription factor that mediates estrogen signaling in hormone-responsive breast cancer (BC) and is the primary target of specific anticancer therapies that although effective can generate resistance phenomena that represents a crucial problem in...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD026864 | Pride
Breast cancer Interaction proteomics Dot1l Endocrine therapy resistance Men1 
TranscriptomicsConcomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma
Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor ...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-19040 | biostudies-arrayexpress
TranscriptomicsA cDNA microarray analysis was performed on HepG2 or L-02 cells with either vectors or constructs expressing MEN1
Menin, the product of the MEN1 gene in humans (Men1 in mice), is responsible for the inherited tumor syndrome, multiple endocrine neoplasia type 1 (MEN1). menin interacts with the trithorax group (trxG) proteins (Drosophila) and the mixed-lineage leukemia (MLL) (humans) histone methyltransferase (HM...
ORGANISM(S): Homo sapiens 
2015-07-07 | E-GEOD-70556 | biostudies-arrayexpress
TranscriptomicsNHGRI Menin ChIP-Chip
Multiple endocrine neoplasia type I (MEN1) is a familial cancer syndrome characterized primarily by tumors of multiple endocrine glands. The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithor...
ORGANISM(S): Homo sapiens 
2006-07-24 | E-GEOD-5357 | biostudies-arrayexpress
TranscriptomicsExpression data from pancreatic islets from Men1flf RIP-Cre mice, Rbp2flf RIP-Cre mice, Men1flf Rbp2flf RIP-Cre mice and matched control.
The menin tumor suppressor protein (Men1) is deficient in many endocrine tumors and forms an active complex with MLL family histone methyltransferases. This Men1 complex promotes histone H3 lysine 4 trimethylation at target loci including homeobox genes and cyclin-dependent kinase inhibitor genes. ...
ORGANISM(S): Mus musculus 
2011-07-25 | E-GEOD-26978 | biostudies-arrayexpress
GenomicsDynamic epigenetic regulation by menin during pancreatic islet tumor formation
loss of Men1 in mouse pancreatic islet cells alters the epigenetic landscape of a subset of target genes. H3K4me3 ChIP-seq from either mouse pancreatic islets or mouse pancreatic islet tumors harvested at different stages.
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-63020 | biostudies-arrayexpress
GenomicsLoss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis
Multiple endocrine neoplasia type 1 (MEN1) syndrome is the result of mutations in the MEN1 gene and results in tumor formation via mechanisms that are not well understood. Using a novel genome-wide methylation analysis, we studied tissues from patients with MEN1-parathyroid tumors, tissues from Men1...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-64412 | biostudies-arrayexpress
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