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ProteomicsONGOING CHROMOSOMAL INSTABILITY ACROSS ANEUPLOID SUBTYPES OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA ASSOCIATES WITH DISEASE PROGRESSION
Chromosomal instability (CIN), defined as an increased occurrence of chromosome segregation errors during cell division, is a prominent form of genomic instability (Bakhoum and Avi Landau, 2017). It is the major cause of aneuploidy, an imbalanced complement of whole chromosomes or chromosome arms, w...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD042785 | Pride
Aneuploidy B-cell acute lymphoblastic leukemia Childhood b-all Chromosomal instability 
TranscriptomicsExpression of FUS-CHOP fusion protein in immortalized/transformed human Mesenchymal Stem Cells drives mixoid liposarcoma formation
Although different sarcomas have been modeled in mice upon expression of fusion oncogenes in MSCs, sarcomagenesis has not been successfully modeled in human MSCs (hMSCs). We report that FUS-CHOP, a hallmark fusion gene in mixoid liposarcoma (MLS), has an instructive role in lineage commitment, and i...
ORGANISM(S): Homo sapiens 
2013-06-18 | E-GEOD-48030 | biostudies-arrayexpress
TranscriptomicsGene expression profile of DLL4+ and DLL4- Hemato-Endothelial Progenitors (HEPs) subpopulations
In hESCs, expression of the Notch ligand DLL4 parallels the emergence of bipotent hematoendothelial progenitors (HEPs) and promotes their hematopoietic differentiation. During differentiation, DLL4 is only expressed in a subpopulation of HEPs. To study the developmental fate of the two subpopulation...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-56881 | biostudies-arrayexpress
TranscriptomicsFLT3 activation cooperates with MLL-AF4 fusion gene to abrogate the hematopoietic specification of human ESCs
MLL-AF4 is a hallmark genomic aberration which arises prenatally in high-risk infant acute lymphoblastic leukemia (ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hemato-endothelial specification but was not sufficient for transformation. Additional cooperating genetic insults seem requi...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-40103 | biostudies-arrayexpress
TranscriptomicsThe differentiation stage of p53- and Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development (part I)
We have previously reported that the deficiency of p53 alone or in combination with Rb (Rb-/- p53-/-) in adipose-derived MSCs (ASCs) promotes leiomyosarcoma-like tumors in vivo. Here, we hypothesized that the source of MSCs and/or the cell differentiation stage could determine the phenotype of sarco...
ORGANISM(S): Mus musculus 
2013-01-27 | E-GEOD-43781 | biostudies-arrayexpress
UnknownOptimizing Propagation of Staphylococcus aureus Infecting Bacteriophage vB_SauM-phiIPLA-RODI on Staphylococcus xylosus Using Response Surface Methodology.
Not available
S-EPMC5923447 | biostudies-literature
TranscriptomicsThe differentiation stage of p53- and Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development (part II)
We have previously reported that the deficiency of p53 alone or in combination with Rb (Rb-/- p53-/-) in adipose-derived MSCs (ASCs) promotes leiomyosarcoma-like tumors in vivo. Here, we hypothesized that the source of MSCs and/or the cell differentiation stage could determine the phenotype of sarco...
ORGANISM(S): Mus musculus 
2013-01-28 | E-GEOD-43803 | biostudies-arrayexpress
UnknownFeasibility and Preliminary Effects of Adding Percutaneous Electrical Nerve Stimulation to a Pain Education and Exercise Program in Patients with Knee Osteoarthritis: A Pilot Randomized Controlled Trial.
Not available
S-EPMC12841921 | biostudies-literature
UnknownBisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo.
Not available
S-EPMC10294797 | biostudies-literature
TranscriptomicsGene expression profile of HoxA9 over expressing and empty vector (EV) control Hemato-Endothelial Progenitors (HEPs) subpopulations
During hematopoietic differentiation of hESCs, HOXA9 expression parallels hematopoietic development but is restricted to the hemogenic precursors (HEP, CD31+CD34+CD45-), and diminishes as HEPs differentiate into blood cells (CD45+). Enforced expression of Hoxa9 in hESCs robustly promoted differentia...
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-61017 | biostudies-arrayexpress
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