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TranscriptomicsIdentification of latent tuberculosis infection-related microRNAs in human U937 macrophages expressing Mycobacterium tuberculosis Hsp16.3
Latent tuberculosis infection (LTBI) relies on a homeostasis of macrophages and Mycobacterium tuberculosis (Mtb). The small heat shock protein, Mtb Hsp16.3 (also known as latency-associated antigen), plays an important role in Mtb persistence within macrophages. However, the mechanism of LTBI remain...
ORGANISM(S): Homo sapiens 
2014-03-17 | E-GEOD-54630 | biostudies-arrayexpress
UnknownRandomized controlled trial: moxibustion and acupuncture for the treatment of Crohn's disease.
Not available
S-EPMC4138481 | biostudies-literature
ProteomicsProteomics of monocytes stimulated by Candida albicans
As innate immune cells, monocytes play a central role in antifungal immunity. Using proteome studies in primary human monocytes, which were stimulated by Candida albicans (yeast) in vitro. Here we describe the changes of proteins in monocytes and demonstrate that in the early stage of infection, th...
ORGANISM(S): Homo Sapiens 
2021-03-04 | PXD024515 |
ProteomicsOmics analysis reveals striking effects of progesterone receptor on mitochondria and mitochondria-mediated apoptosis independent of caspases in Breast Cancer cells
The role of progesterone receptor (PR) in breast cancer remains controversial with conflicting reports from both clinical and laboratory studies. To address these discrepancies, we conducted an integrated omics analysis using MCF-7 cells with elevated PR expression (MCF-7PR) through transfection. Tr...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD061206 | Pride
Mcf-7pr cells Lc-ms/ms 
ProteomicsProteome profiling of normal epithelium, tubular adenoma, tubulovillous adenoma, high-grade neoplasia, cancer tissues in colorectum
Most of the carcinogenesis of colorectal cancer (CRC) follows the normal-adenoma-carcinoma (N-A-C) sequence. We aimed to identify the key proteins in the N-A-C sequence and describe the proteomic pattern of tubular adenoma, tubulovillous adenoma and high-grade neoplasia. This study used high-resolut...
ORGANISM(S): Homo Sapiens 
2021-01-30 | PXD023899 |
TranscriptomicsGenome-wide expression analysis of human fibroblasts and converted neurons
Human fibroblasts can be directly converted into cholinergic neurons by Neurogenin 2 (Neurog2 or NGN2) under the treatments of small molecules. Genome-wide analysis of gene expression was performed to examine the similarity of converted neurons to samples from human brain or spinal cord. Total RNA o...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-45954 | biostudies-arrayexpress
UnknownAssociation between GLIM-diagnosed malnutrition and quality of life in older patients with cancer.
Not available
S-EPMC12275700 | biostudies-literature
ProteomicsQuantitative label-free proteomic analysis of Wdr47+/+ and Wdr47-/- mouse motile cilia
Two 75-cm2 flasks of ependymal cells derived from ten E18.5 Wdr47+/+ or Wdr47-/- embryos at the day 10 post serum starvation were harvested and motile cilia were purified for quantitative label-free proteomic analysis.
ORGANISM(S): Mus Musculus 
2021-09-07 | PXD028219 |
ProteomicsCharacterization of progressive denaturation and unfolding intermediates of proteins by fast cross-linking using di-ortho-phthalaldehyde
Chemical cross-linking of proteins coupled with mass spectrometry (CXMS) is widely used in protein structural analysis. In this study we develop a new class of non-hydrolyzable amine-selective di-ortho-phthalaldehyde (DOPA) cross-linkers, one of which is DOPA2. Cross-linking of proteins with DOPA2 i...
ORGANISM(S): Staphylococcus Aureus Bos Taurus 
2021-12-20 | PXD030552 |
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
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