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ProteomicsFlucloxacillin-modified proteins identified in primary human hepatocytes
Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver injury. Although expression of HLA-B*57:01 increases susceptibility, little is known of the pathological mechanisms involved in the induction of the clinical phenotype. Irreversible protein modification is...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038581 | Pride
Primary human hepatocytes Flucloxaxillin Protein modification 
ProteomicsRetinal Proteomic Alterations and Combined Transcriptomic-proteomic Analysis in the Early Stages Progression of a Mouse Model of X-Linked Retinoschisis
X-linked retinoschisis (XLRS) is among the most common inherited degenerative retinopathies. Functional impairment of RS1 protein is the cause of XLRS, which presents childhood onset with typical structural and functional alterations. However, the molecular mechanisms underlying RS1 malfunction rema...
ORGANISM(S): Mus Musculus 
2022-02-27 | PXD031901 |
ProteomicsNaturally processed flucloxacillin haptenated HLA ligands
This study has demonstrated that natural flucloxacillin haptenated HLA-B*57:01 ligands arepresented by antigen presenting cells through multiple pathways. Identification of such epitopes will help to define the chemical signals responsible for drug-induced immunological disease.
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD020137 | Pride
Dili Hla-b*57:01 Drug hypersensitivity Flucloxacillin 
ProteomicsLD4172 100nM and LD4172NC 100nM treated MDA_MB_231 cell line global proteomics
1 million MDAMB231 cells were seeded in 6-well plates. On the following day, MBAMB231 cells were treated in triplicates with DMSO, LD4172 (100 nM) or LD4172-NC (100 nM) for 6 hours. Cells were washed with ice-cold PBS three times. The cell pellets were lysed, reduced, alkylated, and digested by Easy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-07 | MSV000092377 | MassIVE
ProteomicsLD4172 and LD4172NC treated MDA_MB_231 cell line global proteomics
1 million MDAMB231 cells were seeded in 6-well plates. On the following day, MBAMB231 cells were treated in triplicates with DMSO, LD4172 (100 nM) or LD4172-NC (100 nM) for 6 hours. Cells were washed with ice-cold PBS three times. The cell pellets were lysed, reduced, alkylated, and digested by Easy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-05 | MSV000092348 | MassIVE
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