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ProteomicsThe protection of Evodiamine against Ulcerative Colitis and Colorectal Cancer via anti-inflammation
Evodiamine (Evo), a kind of alkaloid mostly extracted from Tetradium ruticarpum, which has many pharmacological functions, such as antidiarrheal, antiemetic, and antiulcer effects. In this study, the effects of Evo were investigated in DSS-induced ulcerative colitis (UC) mice and C57BL/6-ApcMinC/Gpt...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD027745 | Pride
Colorectal cancer Inflammation Nf-κb Ulcerative colitis Evodiamine 
ProteomicsCPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells
Cancer stem cells (CSCs) play crucial roles in cancer progression, immune evasion, drug resistance, and recurrence. Understanding the mechanisms behind CSCs generation and stemness maintenance is vital for early cancer diagnosis and treatment. Here, we unveil that carnitine palmitoyltransferase 1A (...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059026 | Pride
Mff Stemness maintenance Cpt1a Ovarian cancer stem cells Mams 
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