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GenomicsGenome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors (ChIP-Seq)
Inactivating mutations in the MEN1 gene predisposing to the multiple endocrine neoplasia type 1 (MEN1) syndrome can also cause sporadic pancreatic endocrine tumors. MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes that trimethylate histone H3 at lysine 4 (H3K...
ORGANISM(S): Mus musculus 
2012-06-01 | E-GEOD-37774 | biostudies-arrayexpress
TranscriptomicsNHGRI Menin ChIP-Chip
Multiple endocrine neoplasia type I (MEN1) is a familial cancer syndrome characterized primarily by tumors of multiple endocrine glands. The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithor...
ORGANISM(S): Homo sapiens 
2006-07-24 | E-GEOD-5357 | biostudies-arrayexpress
TranscriptomicsGenome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors
This SuperSeries is composed of the following subset Series: GSE37774: Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors (ChIP-Seq) GSE37775: Genome-wide characterization of menin-dependent H3K4me3 reve...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-37776 | biostudies-arrayexpress
TranscriptomicsMenin-regulated genes in bone marrow B-cell progenitors
MLL1 translocations encode fusion proteins retaining the N-terminus of MLL1, which interacts with the tumor suppressor, menin. This interaction is essential for leukemogenesis, thus is a promising drug target. However, wild-type MLL1 plays a critical role in sustaining hematopoietic stem cells (HSCs...
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-49120 | biostudies-arrayexpress
TranscriptomicsThe Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-49968 | biostudies-arrayexpress
ProteomicsMulti-omics analysis of MEN1 missense mutations identifies disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity
Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other types of cancers. The MEN1 gene product, menin, is involved in transcriptional and chromati...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031928 | Pride
Greencut&run 
ProteomicsInteractome of menin in triple negative breast cancer cell line
The tumor suppressor menin has dual functions, acting either as a tumor suppressor or as an oncogene/oncoprotein, depending on the oncological context. Triple-negative breast cancer (TNBC) is characterized by lack of expression of the estrogen receptor, progesterone receptor, and human epidermal gro...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024176 | Pride
Lc-msms Ap-ms Triple negative breast cancer Menin Interactome 
TranscriptomicsDifferentially regulated genes in adipocytes derived from Men1-null vs WT mouse embryonic stem cells
MEN1 is a tumor suppressor gene loss of which causes lipoma (fatty tumors under the skin) and many other endocrine and non-endocrine tumors. It's target genes in fat cells (adipocytes) are unknown. Gene expression in adipocytes that were in vitro differentiated from mouse embryonic stem cells (mES...
ORGANISM(S): Mus musculus 
2016-02-03 | E-GEOD-65859 | biostudies-arrayexpress
GenomicsDynamic epigenetic regulation by menin during pancreatic islet tumor formation
loss of Men1 in mouse pancreatic islet cells alters the epigenetic landscape of a subset of target genes. H3K4me3 ChIP-seq from either mouse pancreatic islets or mouse pancreatic islet tumors harvested at different stages.
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-63020 | biostudies-arrayexpress
GenomicsThe Menin–Bach2 axis is critical for regulating CD4 T cell senescence and homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanisms remain unclear. We found that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, accompanied by the senescence-associated secretory phenotype (SASP) after antigenic stimulati...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-53831 | biostudies-arrayexpress
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