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GenomicsUBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [ChIP-seq]
UBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [ChIP-seq]
PRJNA1272575 | ENA
GenomicsUBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [RNA-seq]
UBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [RNA-seq]
PRJNA1272588 | ENA
TranscriptomicsUBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [RNA-seq]
The chromatin adaptor protein Menin (MEN1) is required by acute leukemias driven by mixed lineage leukemia 1 gene rearrangements (KMT2A-r) for sustained leukemogenesis. Menin inhibitors (MIs), which disrupt the Menin-KMT2A interface leading to downregulation of Menin-KMT2A oncogenic transcriptional ...
ORGANISM(S): Homo sapiens 
2025-08-01 | GSE299103 | GEO
GenomicsUBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [ChIP-seq]
The chromatin adaptor protein Menin (MEN1) is required by acute leukemias driven by mixed lineage leukemia 1 gene rearrangements (KMT2A-r) for sustained leukemogenesis. Menin inhibitors (MIs), which disrupt the Menin-KMT2A interface leading to downregulation of Menin-KMT2A oncogenic transcriptional ...
ORGANISM(S): Homo sapiens 
2025-08-01 | GSE299100 | GEO
UnknownPreclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias.
Not available
S-EPMC11419783 | biostudies-literature
ProteomicsMezigdomide is effective alone and in combination with Menin inhibition in Acute Myeloid Leukemia
Small molecules that target the MENIN-KMT2A protein-protein interaction (Menin inhibitors) have recently entered clinical trials in lysine methyltransferase 2A (KMT2A, MLL1) rearranged (KMT2A-r) and nucleophosmin mutant (NPM1c) acute myeloid leukemia (AML) and are demonstrating encouraging results. ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD041737 | Pride
Menin-kmt2a Menin inhibitor Acute myeloid leukemia Mezigdomide Ikaros 
ProteomicsMezigdomide is effective alone and in combination with Menin inhibition in Acute Myeloid Leukemia
Small molecules that target the MENIN-KMT2A protein-protein interaction (Menin inhibitors) have recently entered clinical trials in lysine methyltransferase 2A (KMT2A, MLL1) rearranged (KMT2A-r) and nucleophosmin mutant (NPM1c) acute myeloid leukemia (AML) and are demonstrating encouraging results. ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD041735 | Pride
Menin-kmt2a Menin inhibitor Acute myeloid leukemia Mezigdomide Ikaros 
UnknownTargeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.
Not available
S-EPMC7614190 | biostudies-literature
UnknownNUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive gene expression in AML.
Not available
S-EPMC11780541 | biostudies-literature
GenomicsTargeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes [CUT&TAG]
Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes [CUT&TAG]
PRJNA922457 | ENA
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