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TranscriptomicsTrancriptional profiling in microvesicles in stimulated (M1 and M2) and unstimulated conditions
Extracellular membrane vesicles (MVs) are powerful biomarkers in several pathological processes. The potential advantage of MVs relays on the assumption that their content reflects processes ongoing in pathologically relevant cell types. Using microarrays, we performed transcriptional profiling in s...
ORGANISM(S): Mus musculus 
2016-06-03 | E-MTAB-1540 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human myoblasts expressing high or low levels of p75NTR
We measured mRNA levels in human culture myoblasts. Myoblasts were separated by magnetic cell sorting according p75NTR expression before RNA was extracted.
ORGANISM(S): Homo sapiens 
2011-07-22 | E-MTAB-383 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis in Dicer knock-out mice
The precise mechanisms by which microRNAs (miRNAs) contribute to the dynamic regulation of gene expression during forebrain development are still partly elusive. Here we show that depletion of miRNAs via genetic inactivation of Dicer after the onset of forebrain neurogenesis profoundly impairs the m...
ORGANISM(S): Mus musculus 
2012-11-14 | E-MTAB-1062 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling in spinal cord of EAE mice treated with iPSC
The possibility of generating neural stem/precursor cells (NPCs) from induced pluripotent stem cells (iPSCs) has opened a new avenue of research that might nurture bench-to bedside translation of novel and more efficient protocols of cell transplantation in central nervous system (CNS) myelin disord...
ORGANISM(S): Mus musculus 
2016-06-03 | E-MTAB-1546 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of peripheral blood mononuclear cells from male and female patients with relapsing remitting multiple sclerosis and healthy controls
We measured global mRNA expression in peripheral blood mononuclear cells (PBMC) from 45 individuals, comprising of 23 RRMS patients and 22 healthy controls. A gender-based case-control analysis was performed to derive the differentially expressed genes (DEG) in women and men. In contrast to the dist...
ORGANISM(S): Homo sapiens 
2012-03-31 | E-MTAB-380 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human astrocytes upon FGF1 stimulation
In a previous study performed in our laboratory, the level of FGF1 RNA was found to be increased in remyelinated multiple sclerosis lesions compared to control brain (unpublished observation). Astrocytes play a key role in multiple sclerosis lesion formation. To shed light on potential FGF1-mediated...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-MTAB-2485 | biostudies-arrayexpress
TranscriptomicsGene expressions data of Multiple Sclerosis stages, Clinical Isolated Syndrome and healthy controls
Clinically Isolated Syndromes (CIS)represent the first clinical episode of an inflammatory demyelinating disorder suggestive of MS. Most CIS will develop relapsing-remitting MS (RR), characterized by clinical and inflammatory attacks followed by periods of recovery and stability. With time, most RR-...
ORGANISM(S): Homo sapiens 
2023-01-31 | E-MTAB-11415 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling in macrophages in stimulated and unstimulated conditions.
Transcriptomes from macrophages at three stages were examined: a) Non-stimulated, b)Stimulated by Interleukin 4, c)Stimulated by LPS and Interferon gamma. Four biological replicate of each experiment were performed.
ORGANISM(S): Mus musculus 
2018-05-31 | E-MTAB-6416 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling in microglia and peripheral macrophages phenotypes during development and neuroinflammation in mouse
Understanding the respective role of microglia and infiltrating monocytes in neuroinflammatory conditions has recently seemed possible by the identification of a specific microglia signature. Here instead we provide evidence that peripheral macrophages may express some of the most commonly described...
ORGANISM(S): Mus musculus 
2020-10-12 | E-MTAB-8059 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling in embryonic stem cells
Human pluripotent stem (hPS) cells (both embryonic and induced) have emerged as a powerful tool for developmental biology studies, genetic and chemical screens, and regenerative medicine for neurological diseases, as they can generate different neuronal subtypes. We performed genome-wide expression ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-MTAB-1080 | biostudies-arrayexpress
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