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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prefrontal cortex (BA10)
We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection. By comparing the gene expression profiles of similar but distinctive mental disord...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12654 | biostudies-arrayexpress
MetabolomicsA Metabolomic Approach for Predicting Diurnal Changes in Cortisol

INTRODUCTION: The dysregulation of cortisol secretion has been associated with a number of mental health and mood disorders. However, diagnostics for mental health and mood disorders are behavioral and lack biological contexts.

OBJECTIVES: The goal of this ...

2021-09-23 | MTBLS1206 | MetaboLights
MetabolomicsDisorders of gut microbiota and fecal-serum metabolic patterns are associated with pulmonary tuberculosis and pulmonary tuberculosis co-morbid type 2 diabetes mellitus

BACKGROUND: Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are prevalent chronic diseases with substantial implications for human health. DM patients are more susceptible to PTB, which exacerbates diabetes-related complications. However, the complex molecular mechanisms ...

2023-12-15 | MTBLS8729 | MetaboLights
GenomicsInfluence of mental health medication on microbiota in the elderly population in the Valencian region
Microbiota and mental health medication
PRJEB56919 | ENA
ProteomicsAdvanced in vitro safety assessment of herbal medicines for the treatment of non-psychotic mental disorders in pregnancy
When confronted with non-psychotic mental disorders, pregnant women often refrain from using synthetic drugs. Instead, they resort to well-known herbal medicines (phytopharmaceuticals) such as St. John's wort, California poppy, valerian, lavender, and hops, which have proven sedative, anxiolytic, or...
ORGANISM(S): Homo sapiens (Human) 
2022-06-27 | PXD031765 | Pride
Valeriana officinalis Humulus lupulus Eschscholzia californica Pregnancy Mental health disorders Lavandula angustifolia Safety Hypericum perforatum 
TranscriptomicsGene expression profile of peripheral blood mononuclear cells in the X-linked alpha thalassemia mental retardation (ATRX) syndrome
ATRX is a severe X-linked disorder characterized by mental retardation, facial dysmorphism, urogenital abnormalities and alpha-thalassemia. The disease is caused by mutations in ATRX gene, which encodes a protein belonging to the SWI/SNF DNA helicase family, a group of proteins involved in the regul...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-22028 | biostudies-arrayexpress
UnknownGlobal estimates of service coverage for severe mental disorders: findings from the WHO Mental Health Atlas 2017.
Not available
S-EPMC8320004 | biostudies-literature
UnknownMoving towards universal health coverage for mental disorders in Ethiopia.
Not available
S-EPMC6388484 | biostudies-literature
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