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ProteomicsSelective regulation of aspartyl intramembrane protease activity by calnexin
Signal peptide peptidase-like 2c (SPPL2c) is a testis-specific aspartyl intramembrane protease that contributes to male gamete function both by catalytic and non-proteolytic mechanisms. Here, we provide an unbiased characterisation of the in vivo interactome of SPPL2c identifying the ER chaperone ca...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052965 | Pride
Co-ip Signal peptide peptidase-like 2c Mouse Calnexin Sppl2c Testis 
ProteomicsC11orf94/Frey is a key regulator for male fertility by controlling sperm fusion complex assembly
The sperm fusion complex built around the Izumo1 protein is the key male factor for mediation of gamete fusion. Loss of several complex members leads to male infertility. Here, we provide a detailed characterisation of the C11orf94/Frey protein which acts as central chaperone for assembly of the spe...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD030545 | Pride
Ap-ms Gamete fusion Label-free quantitative co-ip Male infertility Mouse Izumo1 C11orf94/frey Lc-ms/ms 
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