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ProteomicsQuantitative Proteomics of SPPL2c overexpressing HEK cells
Signal peptide peptidase-like 2c (SPPL2c) is the only member of the GxGD type intramembrane-cleaving aspartyl proteases that so far has not been assigned any substrates and thus its capability of proteolysis and its physiological function remain enigmatic. Based on a surprisingly high expression of ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-12 | PXD011923 | Pride
Sppl2c Hek cells 
ProteomicsProteomics of testis from SPPL2c KO mice
Signal peptide peptidase (SPP) and the four homologous SPP-like (SPPL) proteases constitute a family of intramembrane aspartyl proteases with selectivity for type II-oriented transmembrane segments. Here, we have analysed the physiological function of the orphan protease SPPL2c, previously considere...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-12 | PXD011922 | Pride
Mouse Testis 
UnknownThe intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.
Not available
S-EPMC6399600 | biostudies-literature
ProteomicsSelective regulation of aspartyl intramembrane protease activity by calnexin
Signal peptide peptidase-like 2c (SPPL2c) is a testis-specific aspartyl intramembrane protease that contributes to male gamete function both by catalytic and non-proteolytic mechanisms. Here, we provide an unbiased characterisation of the in vivo interactome of SPPL2c identifying the ER chaperone ca...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052965 | Pride
Co-ip Signal peptide peptidase-like 2c Mouse Calnexin Sppl2c Testis 
UnknownExome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease.
Not available
S-EPMC7910483 | biostudies-literature
UnknownThe intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban
Not available
S-SCDT-EMBOR-2018-46449-T | biostudies-other
UnknownSignal Peptide-Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins
Not available
S-SCDT-EMBOR-2018-46451-T | biostudies-other
UnknownSignal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins.
Not available
S-EPMC6399617 | biostudies-literature
UnknownThe transmembrane domain of Frey1 harbors a transplantable inhibitory motif for intramembrane proteases.
Not available
S-EPMC10234869 | biostudies-literature
UnknownScreening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease.
Not available
S-EPMC7686230 | biostudies-literature
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