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Inter-organelle membrane contacts especially mitochondria-endoplasmic reticulum contacts (MERC) conduct important biological functions including exchange of lipids and ions, and modulation of membrane dynamics. Alterations of inter-organelle membrane contacts have been implicated with the pathogenes...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035801 | Pride
Our study has shown that during the initiation of ER-stress the oxidoreductase ERO1⍺ covalently interacts with PERK at the MERCs domain. The complex promotes oxidization of MERC proteins and controls mitochondrial dynamics to adapt to new energy needs.
ORGANISM(S): Homo Sapiens (human) 
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