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MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
GenomicsWGS of a serie of Arabidopsis thaliana tetrad's products to study the role of RECQ4A, RECQ4B, FIGL1 and FANCM genes in the rate, nature and distribution of meiotic recombination products (CO and NCO)
In this study, two accessions of Arabidopsis thaliana (Columbia and Landsberg erecta) were crossed and tetrads were obtained using thanks to the the quartet mutation, which keeps the 4 haploid pollen grains from a single meiosis attached together. By fertilising a plant (of ecotype Columbia) with a ...
ORGANISM(S): Arabidopsis thaliana 
2024-12-02 | E-MTAB-14435 | biostudies-arrayexpress
ProteomicsLC-MS3 analysis of Herc1-knockout mouse MLL/AF9 acute myeloid leukemia cells
Our CRISPR-based pharmacogenomic screening identified the E3 ubiquitin ligase Herc1 as a key modulator of sensitivity to cytarabine (Ara-C) chemotherapy in the MLL/AF9 (MA) mouse AML model both in vitro and in vivo. To identify the intracellular proteins whose abundance is modulated by Herc1, we per...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-08 | PXD054402 | Pride
Herc1 Mouse Lc-ms3 Acute myeloid leukemia 
UnknownA Canadian consensus-based list of urgent and specialized in-hospital trauma care interventions to assess the accuracy of prehospital trauma triage protocols: a modified Delphi study.
Not available
S-EPMC10069413 | biostudies-literature
UnknownAssessment of surgical competence for neck dissection: a pilot study.
Not available
S-EPMC8916022 | biostudies-literature
GenomicsWhole-genome resequencing of F1* populations from Arabidopsis Ler
This experiment aims at analyzing crossover distribution in male and female meiosis, in the Arabidopsis pure Ler. Wild-type Ler seeds were subjected to EMS mutagenesis, and four independent M2 plants were crossed to produce two independent F1*, which were heterozygous for a set of EMS mutations. The...
ORGANISM(S): Arabidopsis thaliana 
2022-06-14 | E-MTAB-11248 | biostudies-arrayexpress
GenomicsWhole-genome resequencing of F1 populations from Arabidopsis Ler
This experiment aims at analyzing crossover distribution in male and female meiosis, in the Arabidopsis pure Ler. Wild-type Ler seeds were subjected to EMS mutagenesis, and four independent M2 plants were crossed to produce two independent F1*, which were heterozygous for a set of EMS mutations. The...
ORGANISM(S): Arabidopsis thaliana 
2022-06-14 | E-MTAB-11251 | biostudies-arrayexpress
GenomicsWhole-genome resequencing of F1* populations from Arabidopsis Col
This experiment aims at analyzing crossover distribution in female and male meiosis, in the Arabidopsis pure Col. Wild-type Col seeds were subjected to EMS mutagenesis, and four independent M2 plants were crossed to produce two independent F1*, which were heterozygous for a set of EMS mutations. The...
ORGANISM(S): Arabidopsis thaliana 
2022-06-14 | E-MTAB-11249 | biostudies-arrayexpress
GenomicsWhole-genome resequencing of F1 populations from Arabidopsis Col
This experiment aims at analyzing crossover distribution in male and female meiosis, in the Arabidopsis pure Col. Wild-type Col seeds were subjected to EMS mutagenesis, and four independent M2 plants were crossed to produce two independent F1*, which were heterozygous for a set of EMS mutations. The...
ORGANISM(S): Arabidopsis thaliana 
2022-06-14 | E-MTAB-11250 | biostudies-arrayexpress
UnknownThe effect of primary care on potentially avoidable hospitalizations in France: a cross-sectional study.
Not available
S-EPMC7106616 | biostudies-literature
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