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Transcriptomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [GRO-seq]
Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatiz...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55903 | biostudies-arrayexpress
Genomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [Drug-seq]
Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatiz...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55901 | biostudies-arrayexpress
TranscriptomicsEnhancer Activation Requires Trans-Recruitment of a Mega Transcription Factor Complex
This SuperSeries is composed of the SubSeries listed below. Enhancers provide critical information directing cell-type specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here we report that the most strongly activated es...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-60272 | biostudies-arrayexpress
GenomicsEnhancer Activation Requires Trans-Recruitment of a Mega Transcription Factor Complex (ChIP-seq)
Enhancers provide critical information directing cell-type specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here we report that the most strongly activated estrogen (E2)-responsive enhancers are characterized by trans-r...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-60270 | biostudies-arrayexpress
TranscriptomicsEnhancer Activation Requires Trans-Recruitment of a Mega Transcription Factor Complex (Gro-seq)
Enhancers provide critical information directing cell-type specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here we report that the most strongly activated estrogen (E2)-responsive enhancers are characterized by trans-r...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-60271 | biostudies-arrayexpress
GenomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [ChIP-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64483 | biostudies-arrayexpress
TranscriptomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [GRO-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64515 | biostudies-arrayexpress
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