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TranscriptomicsMerlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we show that the closed, growth inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4DCAF1, and supp...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-19305 | biostudies-arrayexpress
TranscriptomicsGrowth inhibition by Merlin expression correlates with a cross-tissue transcriptional signature
We have found a broad case of tumour suppressor hypersensitivity for Merlin in cancer: Merlin expression in Merlin deficient cells (but not Merlin wild type cells) strongly suppresses proliferation regardless of tumour type or of additional somatic mutations. To study how Merlin selectively induced ...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-53494 | biostudies-arrayexpress
ProteomicsIdentification of Merlin binding proteins
To identify proteins interacting with Merlin in response to calcium signaling, Flag-tagged Merlin was stably transduced into LN229 cells. These cells and empty vector-transduced LN229 cells were treated with DMSO or thapsigargin for 15 minutes and subjected to immunoprecipitation followed by Mass Sp...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-12-07 | PXD021058 | Pride
Calcium Nf2 Immunoprecipitation Merlin 
ProteomicsIdentification of Merlin ubiquitination sites
To identify the ubiquitination sites on Merlin, Flag-tagged wild-type Merlin or the S518D mutant were stably transduced into LN229 cells. These cells were treated with thapsigargin for 15 minutes and subjected to immunoprecipitation and followed by Mass Spectrometry.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-12-07 | PXD021057 | Pride
Calcium Nf2 Ubiquitination Ubiquitin Merlin 
ProteomicsMerlin S13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features
Meningiomas are the most common primary intracranial tumors and are associated with inactivation of the tumor suppressor NF2/Merlin, but one-third of meningiomas retain Merlin expression and typically have favorable clinical outcomes. Biochemical mechanisms underlying Merlin-intact meningioma growth...
ORGANISM(S): Homo sapiens (Human) 
2024-07-04 | PXD053578 | Pride
Wnt signaling Proximity labeling Meningioma Mri Phosphoproteomics 
ProteomicsProteomic analysis of the NF2/Merlin Interactome by Proximity Biotinylation
Neurofibromatosis type 2 is an inherited neoplastic disease consisting of schwannomas, meningiomas, and ependymomas that is caused by inactivation of the tumor suppressor gene NF2. The NF2 gene product, merlin, has no intrinsic catalytic activity; its tumor suppressor function is mediated through t...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-25 | PXD012017 | Pride
Proximity biotinylation Schwann cell. Nf2 Neurofibromatosis type 2 Merlin Interactome Bioib 
GenomicsMerlin rescue drives Wnt signalling
Merlin rescue drives Wnt signalling
PRJNA930687 | ENA
TranscriptomicsGene expression signature regulated by cell density and Merlin/NF2 knockdown in HMLE cells
Merlin has been implicated in contact-dependent inhibition of proliferation To define genes regulated by Merlin and study their relationship to cell density-dependent gene expression, microarray experiments were performed after Merlin depletion in HMLE cells at both high and low cell densities. HMLE...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-53493 | biostudies-arrayexpress
TranscriptomicsMerlin rescue drives Wnt signalling
To investigate the effect of Merlin rescue on cell proliferation in 3D, we grew subcutaneous xenografts from NF2-deficient CH-157MN meningioma cells harboring doxycycline inducible WT-Merlin. Mice were treated with or without doxycycline and Merlin induction was confirmed 24 hours after induction wi...
ORGANISM(S): Mus musculus Homo sapiens 
2023-08-07 | GSE224347 | GEO
GenomicsMerlin Controls Limb Development and Thumb Formation by Regulating Primary Cilia-Hedgehog Signaling
Merlin Controls Limb Development and Thumb Formation by Regulating Primary Cilia-Hedgehog Signaling
PRJNA1255523 | ENA
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