Sort   by:  
 Page size 
ProteomicsTyrosine phosphorylation of IQGAP1 in the MET pathway
Mass spectrometry was used to determine IQGAP1 is a substrate of MET and c-Src, and is phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src cellular activity.
ORGANISM(S): Human 
MSV000086089 | MassIVE
Transcriptomicsc-MET inhibitor inducing KSHV+ primary effusion lymphoma apoptosis
KSHV is a principal causative agent of primary effusion lymphoma (PEL). Despite this knowledge about the close relationship between HGF/c-MET network and solid tumors development, the role of HGF/c-MET in KSHV-related malignancies remains mostly unclear. We report that HGF/c-MET pathway is highly ac...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-70594 | biostudies-arrayexpress
TranscriptomicsMet Expression Signature in Hepatocytes
To identify HGF/Met regulated genes, we performed expression microarray analysis after inducible activation of Met receptor in primary cultures of hepatocytes established from wild-type control (Alb-Cre +/-) and Met conditional knockout mice (Alb-Cre +/-; Met Fl/Fl). Total RNA was isolated from untr...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-4451 | biostudies-arrayexpress
GenomicsCupriavidus sp. Met-2
Cupriavidus sp. Met-2 Genome sequencing
PRJNA1087127 | ENA
Proteomicshepatocyte grwoth factor receptor (MET) LC-MSMS
MET, the receptor for hepatocyte growth factor (HGF), is involved in wide variety of biological events and its aberrant activation is implicated in the pathogenesis of cancer. Especially, MET signaling is associated with resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor...
ORGANISM(S): Homo sapiens (Human) 
2023-04-07 | PXD029295 | Pride
Glycosylation Hepatocyte grwoth factor receptor (met) 
TranscriptomicsTranscription profiling by array of mammospheres derived from tumors of mice harboring Wnt/Met signaling mutations treated Wnt and MET pathway inhibitors
The combined activation of Wnt/ß-catenin and MET/HGF is required for mammary cancer stem cell (MaCSC) maintenance. We generated mammospheres derived from tumors of mice harboring Wnt/Met signaling mutations on which we performed microarray analysis to evaluate gene expression signatures controlled b...
ORGANISM(S): Mus musculus 
2014-02-18 | E-GEOD-35899 | biostudies-arrayexpress
TranscriptomicsThe MET oncogene is a functional marker of a glioblastoma stem cell subtype and drives the invasive phenotype
Eighteen independent neurospheres derived from patients affected by primary glioblastoma were grouped into “classical”, “mesenchymal” or “proneural” subtypes according to analysis of genetic lesions and gene expression profiling. Here we show that expression of the MET oncogene, encoding the tyrosin...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-36426 | biostudies-arrayexpress
TranscriptomicsProgranulin A mediated MET signalling is essential for liver morphogenesis in zebrafish
Regulation of embryonic liver growth remains largely elusive. Progranulin has been discussed in pathological liver growth; however, the functional role of Pgrn in embryonic liver growth has never been addressed. Knockdown of GrnA, the orthologue of mammalian pgrn in zebrafish, displayed a deficien...
ORGANISM(S): Danio rerio 
2010-11-10 | E-GEOD-19211 | biostudies-arrayexpress
TranscriptomicsLunatic fringe deficiency cooperates with the Met/Caveolin amplicon to induce basal-like breast cancer
Mammary specific deletion of Lfng induces basal-like and claudin-low tumors with accumulation of Notch intracellular domain fragments, increased expression of proliferation-associated Notch targets, amplification of the Met/Caveolin locus, and elevated Met and Igf-1R signaling. Tumor DNAs from Lfngf...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-35855 | biostudies-arrayexpress
TranscriptomicsLunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-Like Breast Cancer
SUMMARY: Basal breast cancer has been associated with mutations in a number of specific tumor suppressor genes, however, the mechanism by which these tumors express a basal lineage remains unknown. Notch signaling suppresses mammary stem cell (MaSC) self-renewal, while promoting luminal cell fate s...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-28712 | biostudies-arrayexpress
Sort   by:  
 Page size