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JIB-04 is an inhibitor of Jumonji histone demethylases identified through a cell based screen that measures the reactivation of an epigenetically silenced transgene. The active JIB-04 E-isomer shows selectivity for cancer vs. normal cells affecting both transcriptional patterns and cell viability in...
ORGANISM(S): Homo sapiens 
Background: Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimu...
ORGANISM(S): Homo sapiens 
Peritoneal macrophages of Tyk2-/- and wildtype (wt) mice were compared before and after six hours of LPS treatment. Interferon responsive genes are lower expressed in Tyk2-/- macrophages at the basal level, metabolic genes higher before, but even more after LPS treatment. cDNA from macrophages from ...
ORGANISM(S): Mus musculus 
Effect of mild metal ion-stress (40µM AgNO3, 200µM AsCl3, 2µM CdCl2, 100µM CoCl2, 30µM HgCl2, 1.5mM MnCl2, 1.5mM NiSO4) on cellular metabolism, resp. on transcription - 30min incubation in yeast Saccharomyces cerevisiae
ORGANISM(S): Saccharomyces cerevisiae 
Effect of mild metal ion - stress (500µM AlCl3, 500µM VCl3, 1.5mM ZnCl2) on cellular metabolism, resp. on transcription - 30min incubation in yeast Saccharomyces cerevisiae (JSwt - is a FY derivate; MATaleu2ura3trp1HIS3)
ORGANISM(S): Saccharomyces cerevisiae 
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