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MetabolomicsA pathogen-specific isotope tracing approach reveals metabolic activities and fluxes of intracellular Salmonella

Pathogenic bacteria proliferating inside mammalian host cells need to rapidly adapt to the intracellular environment. How they achieve this and scavenge essential nutrients from the host has been an open question due to the difficulties in distinguishing between bacterial and host metabolites

2023-08-02 | MTBLS1275 | MetaboLights
TranscriptomicsTranscription profiling of S. cerevisiae treated with absence of oxygen or depletion of ATP to investigate control of glycolytic enzyme fluxes
Metabolic fluxes may be regulated "hierarchically," e.g., by changes of gene expression that adjust enzyme capacities (V(max)) and/or "metabolically" by interactions of enzymes with substrates, products, or allosteric effectors. In the present study, a method is developed to dissect the hierarchical...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-9232 | biostudies-arrayexpress
ModelsSmallbone2013 - Yeast metabolic model with linlog rate law
Kieran Smallbone & Pedro Mendes. Large-Scale Metabolic Models: From Reconstruction to Differential Equations. Industrial Biotechnology 9, 4 (2013). Genome-scale kinetic models of metabolism are important for rational design of the metabolic engineering required for industrial biotechnology applicat...
2024-09-02 | BIOMD0000000471 | BioModels
ModelsSmallbone2013 - Yeast metabolic model with modular rate law
Kieran Smallbone & Pedro Mendes. Large-Scale Metabolic Models: From Reconstruction to Differential Equations. Industrial Biotechnology 9, 4 (2013). Genome-scale kinetic models of metabolism are important for rational design of the metabolic engineering required for industrial biotechnology applicat...
2024-09-02 | BIOMD0000000472 | BioModels
ModelsSmallbone2013 - E.coli metabolic model with linlog rate law
Kieran Smallbone & Pedro Mendes. Large-Scale Metabolic Models: From Reconstruction to Differential Equations. Industrial Biotechnology 9, 4 (2013). Genome-scale kinetic models of metabolism are important for rational design of the metabolic engineering required for industrial biotechnology applicat...
2024-09-02 | BIOMD0000000469 | BioModels
ModelsSmallbone2013 - E.coli metabolic model with modular rate law
Kieran Smallbone & Pedro Mendes. Large-Scale Metabolic Models: From Reconstruction to Differential Equations. Industrial Biotechnology 9, 4 (2013). Genome-scale kinetic models of metabolism are important for rational design of the metabolic engineering required for industrial biotechnology applicat...
2024-09-02 | BIOMD0000000470 | BioModels
ModelsSmallbone2013 - Yeast metabolic model with modular rate law, merged with Pritchard 2002
Kieran Smallbone & Pedro Mendes. Large-Scale Metabolic Models: From Reconstruction to Differential Equations. Industrial Biotechnology 9, 4 (2013). Genome-scale kinetic models of metabolism are important for rational design of the metabolic engineering required for industrial biotechnology applicat...
2024-09-02 | BIOMD0000000473 | BioModels
TranscriptomicsTranscription profiling of S. cerevisiae grown in acetate, ethanol and maltose limited conditions to investigate transcriptional regulation in controlling fluxes in central carbon metabolism
In contrast to batch cultivation, chemostat cultivation allows the identification of carbon source responses without interference by carbon-catabolite repression, accumulation of toxic products, and differences in specific growth rate. This study focuses on the yeast Saccharomyces cerevisiae, grown ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-8895 | biostudies-arrayexpress
GenomicsImproving genome-scale metabolic model simulations by measuring exchange fluxes during exponential growth phase
Improving genome-scale metabolic model simulations by measuring exchange fluxes during exponential growth phase
PRJNA1245327 | ENA
ProteomicsGlobal coordination of metabolic pathways in Escherichia coli by active and passive regulation
In this study, we identify the regulatory mechanisms that coordinate catabolism and anabolism in the bacterium Escherichia coli. Integrating protein, metabolite, and metabolic flux changes in genetically implemented gradual catabolic or anabolic limitations, we show that a combination of global and ...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2021-03-03 | MSV000086992 | MassIVE
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