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MetabolomicsTranscriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models

Microorganisms can adopt a quiescent physiological condition which acts as a survival strategy under unfavourable conditions. Quiescent cells are characterized by slow or non-proliferation and deep down-regulation of processes related to biosynthesis. Although quiescence has been described mostly...

2022-02-23 | MTBLS4046 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Metabolome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-17 | MTBLS577 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Lipidome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-21 | MTBLS578 | MetaboLights
TranscriptomicsRaptor/mTORC1-dependent metabolic programming of exit from quiescence underlies T cell activation and fate decisions
Naïve T cells respond to antigen stimulation by exiting from quiescence into clonal expansion and functional differentiation, but the control mechanism is elusive. Here we describe that Raptor/mTORC1-dependent metabolic reprogramming is a central determinant of this transitional process. Loss of Rap...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-51668 | biostudies-arrayexpress
ProteomicsMultiplexed proteomics of a cellular transition from G0 to cell cycle in response to IL-3 activation
There exist similarities and differences in metabolism and physiology between normal proliferative cells and tumor cells. Once a cell enters the cell cycle, metabolic machinery is engaged to facilitate various processes. The kinetics and regulation of these metabolic changes have not been properly e...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-06-21 | MSV000081179 | MassIVE
TranscriptomicsQuiescent Fibroblasts Exhibit High Metabolic Activity
Many cells in mammals exist in the state of quiescence, which is characterized by reversible exit from the cell cycle. Quiescent cells are widely reported to exhibit reduced size, nucleotide synthesis, and metabolic activity. Much lower glycolytic rates have been reported in quiescent compared with ...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-42612 | biostudies-arrayexpress
TranscriptomicsSlu7 is essential for liver differentiation, metabolism and quiescence
The equilibrium between cellular differentiation and proliferation is fundamental for tissue homeostasis. This is particularly important for the liver, a highly differentiated organ with systemic metabolic functions still endowed with unparalleled regenerative potential. Hepatocellular de-differenti...
ORGANISM(S): Homo sapiens 
2014-05-29 | E-GEOD-54090 | biostudies-arrayexpress
TranscriptomicsCandidate pathways for promoting differentiation and quiescence of oligodendrocyte progenitor-like cells in glioblastoma
The mature CNS contains PDGFRA+ ‘oligodendrocyte progenitor cells’ (OPC) which may remain quiescent, proliferate, or differentiate into oligodendrocytes. In human gliomas, rapidly proliferating Olig2+ cells resembling OPCs are frequently observed. We sought to identify, in vivo, candidate pathways u...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-30626 | biostudies-arrayexpress
ProteomicsTXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
Entry and exit from cellular quiescence require dynamic adjustments in nutrient acquisition, yet the mechanisms by which quiescent cells downregulate amino acid (AA) transport remain poorly understood. Here we show that cells entering quiescence selectively target plasma membrane-resident AA transpo...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD066527 | Pride
Nutrient transporter Hect-type ubiquitin ligase Ppxy Quiescence Arrestin Endocytosis 
MetabolomicsCiprofloxacin-induced metabolic disruption and stringent response drives persistent small-colony variants in Staphylococcus aureus

Antibiotic treatment failure in Staphylococcus aureus infections is frequently associated with antimicrobial resistance or the emergence of small-colony variants (SCVs), a metabolically quiescent phenotype that complicates infection management. Here, we show that ciprofloxacin induces a stable SC...

2025-11-19 | MTBLS13343 | MetaboLights
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