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ProteomicsBioinertization of nanoLC/MS/MS systems by depleting metal ions from the mobile phases for phosphoproteomics
We have successfully bioinertized a nanoLC/MS/MS system for the highly sensitive analysis of phosphopeptides by depleting metal ions from the mobile phase. We found that not only the direct contact of phosphopeptides with metal materials, but also the indirect contact with HPLC pump through the mobi...
ORGANISM(S): Homo Sapiens (human) 
2023-03-24 | PXD034942 | JPOST Repository
ProteomicsUpregulation of the AcrAB2NodT efflux pump confers antibiotic resistance at the cost of collateral metal sensitivity
Bacterial resistance to antibiotics (AB) such as β-lactams, fluoroquinolones, and aminoglycosides often emerges through mutations that alter AB targets, reduce membrane permeability, or increase the activity of AB-modifying enzymes and efflux pumps. Yet the physiological costs associated with AB res...
ORGANISM(S): Caulobacter vibrioides 
2026-03-02 | PXD067190 | Pride
Antibiotics Heavy metals Metal sensitivity Stress response Caulobacter Efflux pumps Antibiotic resistance Copper 
TranscriptomicsZinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc
Only a small number of genes are known direct targets of the zinc-responsive transcription factor MTF1; therefore, the aim of this study was to gain a more complete understanding of the MTF-1 regulated zinc-responsive component of the transcriptome. A targeted siRNA was used to deplete MTF1 express...
ORGANISM(S): Homo sapiens 
2016-02-24 | E-GEOD-76510 | biostudies-arrayexpress
TranscriptomicsMetal tolerance in brown trout
This study aimed to investigate the transcriptional differences to metal exposure in two populations of Brown trout. These trout were taken from two separate locations, one population with historic exposure to metals and evidence of metal tolerance, and a second population from a clean environment. ...
ORGANISM(S): Salmo trutta 
2024-10-25 | E-MTAB-10209 | biostudies-arrayexpress
TranscriptomicsSalmonella response to copper and zinc
Salmonella can infect a wide range of hosts and survive in the environment. This invasive pathogen has therefore evolved and acquired specific traits to cope with different, and in most cases unfavorable, conditions. In particular, transition metal ions are widely spread in these niches. These ions ...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2012-03-15 | E-GEOD-35328 | biostudies-arrayexpress
ProteomicsMembrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis
Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a previously unrecognized mechanism in Mycobacterium tuberculosis, the causative agent of tuberculosis, wh...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2025-12-15 | PXD070650 | Pride
Metal binding Tuberculosis Native ms 
TranscriptomicsWhole Adult Organism Transcriptional Profiling of Metal Exposures in Zebrafish
A convergence of technological breakthroughs in the past decade has facilitated the development of rapid screening tools for biomarkers of toxicant exposure and effect. Platforms using the whole adult organism to evaluate the genome-wide response to toxicants are especially attractive. Recent work d...
ORGANISM(S): Danio rerio 
2014-06-10 | E-GEOD-50648 | biostudies-arrayexpress
TranscriptomicsDivergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/Insulin/IGF-receptor pathway
To identify genes that selectively regulate hypoxic sensitivity, we compared the whole-organismal transcriptomes of three daf-2 reduction-of-function alleles, all of which are hypoxia resistant, thermotolerant, and long lived but differ in their rank of severities for these phenotypes. The transcrip...
ORGANISM(S): Caenorhabditis elegans 
2010-06-20 | E-GEOD-18601 | biostudies-arrayexpress
ProteomicsMetal-induced Protein Precipitation in E. coli
Using a range of copper we have utilized Metal-induced Protein Precipitaiton (MiPP) technique to elucidate the copper midpoints of the proteins found in an E. coli proteome. Using bottem-up proteomics techniques and TMT-10 plex isobaric mass-tags we were able to use MiPP to classify proteins based o...
ORGANISM(S): Escherichia coli 
2023-01-03 | PXD035711 | Pride
Precipitiation Sprox Cpp Metal E. coli Copper 
TranscriptomicsTranscriptional response of yellow perch to changes in ambient metal concentrations - a reciprocal field transplantation experiment
Our main objectives wereto investigate the molecular mechanisms involved in metal toxicity and detoxification in the field using juvenile yellow perch subjected to differents levels of this metal exposure. Recent local adaptation to pollution has been evidenced in several organisms inhabiting enviro...
ORGANISM(S): Perca flavescens 
2016-01-11 | E-GEOD-76723 | biostudies-arrayexpress
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