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How cells safeguard essential zinc-dependent functions during zinc deficiency is poorly understood. A long-debated strategy is whether soluble metal-trafficking chaperones exist to prioritize specific zinc-dependent proteins. We identified a eukaryotic family of metallochaperones that physically int...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
Iron is a biochemically critical metal cofactor in enzymes involved in photosynthesis, respiration, nitrate assimilation, nitrogen fixation, and reactive oxygen species defense. Marine microeukaryotes have evolved a phytotransferrin-based iron uptake system to cope with iron scarcity, a major factor...
ORGANISM(S): Phaeodactylum tricornutum (strain CCAP 1055/1) 
2021-03-02 | PXD018022 | Pride
To look at differential expression of membrane-trafficking genes,
we extracted RNA from exponentially growing cultures of T. brucei
bloodstream (BSF) and procyclic (PCF) forms, labelled and competitively
hybridised the cDNA to the microarray. 8 arrays, representing
6 BSF and 5 PCF bi...
ORGANISM(S): Trypanosoma brucei 
We investigated the fungus Aspergillus fumigatus PD-18 responses when subjected to the multimetal combination (Total Cr, Cd2+, Cu2+, Ni2+, Pb2+and Zn2+) in synthetic composite media. To understand how multimetal stress impacts fungal cells at molecular level, the cellular response of A.fumigatus PD-...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2022-05-27 | PXD031741 | Pride
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