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ProteomicsGroEL interaction and folding of MetF studied by hydrogen/deuterium exchange – mass spectrometry
The cylindrical chaperonin GroEL and its cofactor GroES mediate ATP-dependent protein folding in E. coli by transiently encapsulating non-native substrate in a nano-cage formed by the GroEL ring cavity and the lid-shaped GroES. We analyzed the spontaneous and chaperonin-assisted folding of the essen...
ORGANISM(S): Escherichia coli 
2020-03-05 | PXD016666 | Pride
Groel Chaperone Folding Metf Hydrogen/deuterium exchange Chaperonin 
GenomicsUnveiling the Molecular Legacy of Transient Insulin Resistance: Implications for Hepatic Metabolic Adaptability [ChIP-Seq]
Metabolic flexibility (MetF) refers to an organism's capacity to adapt to changes in metabolic supplies and energy demands. MetF involves various organs, such as skeletal muscle, white adipose tissues, and the liver, and plays a critical role in altering fuel selection. Insulin acts as a central coo...
ORGANISM(S): Mus musculus 
2025-07-17 | GSE249841 | GEO
TranscriptomicsUnveiling the Molecular Legacy of Transient Insulin Resistance: Implications for Hepatic Metabolic Adaptability [array]
Metabolic flexibility (MetF) refers to an organism's capacity to adapt to changes in metabolic supplies and energy demands. MetF involves various organs, such as skeletal muscle, white adipose tissues, and the liver, and plays a critical role in altering fuel selection. Insulin acts as a central coo...
ORGANISM(S): Mus musculus 
2025-07-17 | GSE249679 | GEO
GenomicsUnveiling the Molecular Legacy of Transient Insulin Resistance: Implications for Hepatic Metabolic Adaptability [ATAC-Seq]
Metabolic flexibility (MetF) refers to an organism's capacity to adapt to changes in metabolic supplies and energy demands. MetF involves various organs, such as skeletal muscle, white adipose tissues, and the liver, and plays a critical role in altering fuel selection. Insulin acts as a central coo...
ORGANISM(S): Mus musculus 
2025-07-17 | GSE249842 | GEO
TranscriptomicsUnveiling the Molecular Legacy of Transient Insulin Resistance: Implications for Hepatic Metabolic Adaptability [RNA-Seq]
Metabolic flexibility (MetF) refers to an organism's capacity to adapt to changes in metabolic supplies and energy demands. MetF involves various organs, such as skeletal muscle, white adipose tissues, and the liver, and plays a critical role in altering fuel selection. Insulin acts as a central coo...
ORGANISM(S): Mus musculus 
2025-07-17 | GSE249858 | GEO
UnknownSimilar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test.
Not available
S-EPMC8637191 | biostudies-literature
UnknownMetformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis.
Not available
S-EPMC6350585 | biostudies-literature
UnknownThe anticancer effect of metformin targets VDAC1 via ER-mitochondria interactions-mediated autophagy in HCC.
Not available
S-EPMC11671597 | biostudies-literature
UnknownThe folate branch of the methionine biosynthesis pathway in Streptomyces lividans: disruption of the 5,10-methylenetetrahydrofolate reductase gene leads to methionine auxotrophy.
Not available
S-EPMC107064 | biostudies-literature
UnknownMetabolic flexibility to lipid during exercise is not associated with metabolic health outcomes in individuals without obesity.
Not available
S-EPMC11576753 | biostudies-literature
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