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TranscriptomicsTranscription profiling of E. coli groESL(-) cells expressing human Hsp60(wt)/Hsp10 or Hsp60-(p.Val98Ile)/Hsp10 operons
To identify regulatory responses that could give clues as to the cause(s) of the growth arrest observed in E. coli cells expressing mutant Hsp60-(p.Val98Ile) and Hsp10 versus cells expressing wild type Hsp60 and Hsp10, we performed microarray analyses. We reasoned that the decreased chaperonin activ...
ORGANISM(S): Escherichia coli 
2008-06-11 | E-GEOD-10974 | biostudies-arrayexpress
TranscriptomicsTrivalent arsenic inhibits the functions of chaperonin complex
The goal of this study was to identify yeast mutants with arsenite hypersensitivity. Keywords: dose response Matched pools of yeast knockout (YKO) mutants were grown in paired growth media lacking or containing arsenite at various concentrations. The relative abundances of the YKO mutants were profi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-26 | E-GEOD-5973 | biostudies-arrayexpress
MetabolomicsLipidomic characterization of Jurkat-derived T cell line in which the chaperonin complex CCT has been partially silenced
Not available
ORGANISM(S): Homo sapiens 
ST002185 | MetabolomicsWorkbench
GenomicsTreatment of rheumatoid arthritis patients with chaperonin 10
Treatment of rheumatoid arthritis patients with chaperonin 10
PRJNA449066 | ENA
GenomicsDynamics of chaperonin function in live human cells
Dynamics of chaperonin function in live human cells
PRJNA1298779 | ENA
ProteomicsIn situ observation of chaperonin function in protein folding
The GroEL/GroES chaperonin mediates protein folding in bacteria in an ATP-dependent process. Studies in vitro show that the GroEL double-ring and the lid-shaped GroES transiently encapsulate unfolded protein for folding unimpaired by aggregation. To clarify critical aspects of this mechanism, we use...
ORGANISM(S): Escherichia coli 
2024-06-27 | PXD042587 | Pride
Chaperonin Atpase Chaperone Heat shock Folding cage Proteostasis 
TranscriptomicsTreatment of rheumatoid arthritis patients with chaperonin 10
Trial described in Lancet. 2006 Sep 2;368(9538):855-63. Rheumatoid arthritis patients were treated with chaperonin 10, with a dose of 10 mg rCpn10 i.v. twice weekly for 56 days. Blood samples were collected before and after treatment. Microarray analysis described in Hirata et al., Early pregnancy f...
ORGANISM(S): Homo sapiens 
2018-04-07 | GSE112809 | GEO
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75247 | biostudies-arrayexpress
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75410 | biostudies-arrayexpress
ProteomicsChaperonin CCT Checkpoint Function in Basal Transcription Factor TFIID Assembly
TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit composition exist and several TFIID subunits are shared with other complexes, conveying intricate cellular decision making to control subunit allocation and functional assembly of this essential transc...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD011211 | Pride
Proteomics Crystal structure Tfiid Chaperonin cct 
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