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TranscriptomicsLung adenocarcinoma and mesothelioma DNA methylation
Pathologic differentiation of tissue of origin in tumors found in the lung can be challenging, with differentiation of mesothelioma and lung adenocarcinoma emblematic of this problem. Indeed, proper classification is essential for determination of treatment regimen for these diseases, making accurat...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-16559 | biostudies-arrayexpress
ProteomicsWidespread prevalence of a post-translational modification in activation of an essential bacterial DNA damage response
DNA methylation plays central roles in diverse cellular processes, ranging from error-correction during replication to regulation of bacterial defense mechanisms. Nevertheless, certain aberrant methylation modifications can have lethal consequences. The mechanisms by which bacteria detect and respon...
ORGANISM(S): Caulobacter crescentus (strain NA1000 / CB15N) 
2024-02-09 | PXD049136 | Pride
Methylation damage Adaptive response Dna repair Dna damage Bacteria Caulobacter Sos response Bacterial ptms 
TranscriptomicsDNA methylation profiles in the uterus during subclinical endometritis
Post-partum uterine inflammation (endometritis) is associated with lower fertility at both the time of infection and after the inflammation has resolved. It was hypothesized that aberrant DNA methylation may be involved in the sub-fertility associated with post-partum uterine inflammation. The objec...
ORGANISM(S): Bos taurus 
2015-05-07 | E-GEOD-60831 | biostudies-arrayexpress
GenomicsDNA damage drives DNA methylation generation and evolution in plant
DNA damage drives DNA methylation generation and evolution in plant
PRJNA1206087 | ENA
ProteomicsRole of PRMT5 in DNA damage response
Protein arginine methyltransferase (PRMT5) has emerged as a crucial symmetric dimethylating enzyme involved in the methylation of a myriad of substrates critical for epigenetic regulation, DNA damage signalling, RNA splicing, and cell fate decision. Here we have uploaded the PRMT5 interactome with t...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD057645 | Pride
Mitochondrial homeostasis Post translational modification Prmt5 Mitochondrial biogenesis Tfam Mtdna damage 
ProteomicsQuantitiave analysis of protein methylome reveals the cellular response to ionizing radiation
Protein methylation plays important roles in DNA damage signaling. To date, there is still a lack of global profiling of whole-cell methylation changes during the DNA damage response and repair. In this study, using HILIC affinity enrichment combined with MS analysis, we conducted a quantitative ana...
ORGANISM(S): Homo Sapiens 
2022-02-14 | PXD031655 |
TranscriptomicsDNA damage signaling gene array on SMA mouse skeletal muscle
A commercially available gene array (SABiosciences array PAMM-029ZD-12) was used to assay gene expression in skeletal muscle of SMA mice and control littermates. The Taiwanese severe SMA mouse model was used (Hsieh-Li et al. 2000). The array included 84 genes associated with DNA damage detection, DN...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-55481 | biostudies-arrayexpress
TranscriptomicsAltered levels of MOF and decreased levels of H4K16ac correlate with a defective DNA damage response (DDR).
Full title: Altered levels of MOF (member of MYST family histone acetyl transferase) and decreased levels of H4K16ac correlate with a defective DNA damage response (DDR). The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac). Here we show that altered le...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20193 | biostudies-arrayexpress
GenomicsDNA damage drives DNA methylation generation and evolution in plant [RNA-seq]
DNA damage drives DNA methylation generation and evolution in plant [RNA-seq]
PRJNA1128113 | ENA
GenomicsDNA damage drives DNA methylation generation and evolution in plant [BiSulfite-seq]
DNA damage drives DNA methylation generation and evolution in plant [BiSulfite-seq]
PRJNA1128118 | ENA
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