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MetabolomicsMycobacterium tuberculosis VadK required for regulation of the methylcitrate cycle and virulence

The evolution of new enzymatic functions is constrained and guided by the architecture of an organism’s metabolic and regulatory networks and environmental constraints. Here, we identify a kinase that has evolved from pyruvate phosphate dikinase. Through biochemical and systems-lev...

2026-04-21 | MTBLS13906 | MetaboLights
Genomics2-Methylcitrate cycle: a well-regulated controller in Bacillus sporulation
2-Methylcitrate cycle: a well-regulated controller in Bacillus sporulation
PRJNA589283 | ENA
UnknownThe 2-methylcitrate cycle and the glyoxylate shunt in Pseudomonas aeruginosa are linked through enzymatic redundancy.
Not available
S-EPMC11982470 | biostudies-literature
UnknownRegX3-Mediated Regulation of Methylcitrate Cycle in Mycobacterium smegmatis.
Not available
S-EPMC7884335 | biostudies-literature
UnknownThe 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii.
Not available
S-EPMC3593168 | biostudies-literature
Transcriptomics2-Methylcitrate cycle: a well-regulated controller in Bacillus sporulation
To understand which gene(s) are affected by 2-methylcitrate to lead to the delayed sporulation in ∆prpD, we extracted the total RNA from BMB171 and ∆prpD at 12 h for whole genome transcription analysis by RNA sequencing (RNA-Seq). Our RNA-seq data showed that transcriptions of almost all of the SigF...
ORGANISM(S): Bacillus thuringiensis BMB171 
2019-11-14 | GSE140317 | GEO
UnknownIdentification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle.
Not available
S-EPMC135033 | biostudies-literature
UnknownMycobacterium smegmatis GlnR Regulates the Glyoxylate Cycle and the Methylcitrate Cycle on Fatty Acid Metabolism by Repressing icl Transcription.
Not available
S-EPMC7886694 | biostudies-literature
UnknownNew Methylcitrate Synthase Inhibitor Induces Proteolysis, Lipid Degradation and Pyruvate Excretion in Paracoccidioides brasiliensis.
Not available
S-EPMC9865517 | biostudies-literature
ProteomicsMetabolism of host-derived glycolytic products by Mycobacterium tuberculosis requires five metabolic pathways
Bacterial nutrition is a key aspect of host-pathogen interaction and bacteria must adapt to use nutrients available in the host. Lipid droplets-derived fatty acids are considered the major intracellular carbon source for Mycobacterium tuberculosis (Mtb), an intracellular pathogen causing Tuberculosi...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2020-05-26 | PXD010726 | Pride
Lc-msms Mycobacterium tuberculosis Tmt Bacterial nutrition Glucose metabolism Orbitrap 
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