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ProteomicsMETTL17 is an Fe-S cluster checkpoint for mitochondrial translation
Friedreich’s ataxia (FA) is the most common monogenic mitochondrial disease. FA is caused by a depletion of the mitochondrial protein frataxin (FXN), an iron-sulfur (Fe-S) cluster biogenesis factor. To better understand the cellular consequences of FA, we performed quantitative proteome profiling of...
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD045443 | Pride
Mettl17 Friedreich’s ataxia Fxn Fe-s clusters 
UnknownMETTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer.
Not available
S-EPMC10884776 | biostudies-literature
UnknownTesting a Hypothesis of 12S rRNA Methylation by Putative METTL17 Methyltransferase.
Not available
S-EPMC10790355 | biostudies-literature
UnknownMettl15-Mettl17 modulates the transition from early to late pre-mitoribosome.
Not available
S-EPMC11785013 | biostudies-literature
GenomicsRNA-Seq of human colorectal cancer (CRC) cell lines with or without METTL17 knockdown
RNA-Seq of human colorectal cancer (CRC) cell lines with or without METTL17 knockdown
PRJNA998811 | ENA
TranscriptomicsRNA-Seq of human colorectal cancer (CRC) cell lines with or without METTL17 knockdown
To investigate the mRNA profiling in RKO and SW620 cells with or without shRNA-mediated METTL17 knockdown, we performed RNA-seq with the total RNA extracted from the CRC cells.
ORGANISM(S): Homo sapiens 
2023-08-08 | GSE239325 | GEO
GenomicsHomo sapiens
RNA-Seq of human colorectal cancer (CRC) cell lines with or without METTL17 knockdown
PRJNA996516 | ENA
OtherGenetic interaction screen for FXN in K562 cells, to identify genes that are synthetic sick/buffering in the absence of robust Fe-S cluster synthesis
Friedreich’s ataxia (FA) is the most common monogenic mitochondrial disease. FA is caused by a depletion of the mitochondrial protein frataxin (FXN), an iron-sulfur (Fe-S) cluster biogenesis factor. To better understand the cellular consequences of FA, we performed genetic interaction mapping in con...
ORGANISM(S): Homo sapiens 
2023-12-18 | GSE242192 | GEO
UnknownBOLA3 and NFU1 link mitoribosome iron-sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome.
Not available
S-EPMC10681725 | biostudies-literature
UnknownShort-term oral pre-exposure prophylaxis against HIV-1 modulates the transcriptome of foreskin tissue in young men in Africa.
Not available
S-EPMC9720390 | biostudies-literature
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