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TranscriptomicsDetermination of the spatial organization of the FXN gene locus by using Chromosome Conformation Capture technique coupled with High-throughtput sequencing (3C-seq).
Accumulating data from different groups have demonstrated that alteration of post-translational histone modifications is an important underlying mechanism for FXN silencing in FRDA. The relationship between chromatin architecture and histone modification marks in the FXN gene locus is likely to be i...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-42961 | biostudies-arrayexpress
TranscriptomicsEpigenetic therapy for Friedreich ataxia.
We set out to investigate whether a histone deacetylase inhibitor (HDACi) would be effective in an in vitro model for the neurodegenerative disease Friedreich ataxia (FRDA) and to evaluate safety and surrogate markers of efficacy in a phase I clinical trial in patients. In the neuronal cell model, H...
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-65399 | biostudies-arrayexpress
ProteomicsHuman Mitochondria NFS1-ISCU-FXN XL-MS
Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation. FXN deficiency is associated with Friedreich ataxia, a neurodegenerative disease. Using chemical cross-linking (XL) accompanied with LC-MS/MS, we studied the the interac...
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD006938 | Pride
Mitochondria Iron-sulfur cluster Xl-ms 
ProteomicsHuman Mitochondrial NFS1-FXN XL LS-MS/MS
Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation. FXN deficiency is associated with Friedreich ataxia, a neurodegenerative disease. Using chemical cross-linking (XL) accompanied with LC-MS/MS, we studied the the interac...
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD006928 | Pride
Mitochondria Iron-sulfur cluster Xl Lc-ms/ms 
ProteomicsFXN specific Nanobody Interaction between FXN and NB in HEK-293T Cells: Co-immunoprecipitation and LC-MS
Co-immunoprecipitation was used to investigate whether the Nanobodies can interact with FXN in a cellular environment. Particularly, FXN-Specific NBs were transfected into HEK-293T cells and immunoprecipitation was performed with an anti his antibody.
ORGANISM(S): Homo sapiens (Human) 
2025-12-17 | PXD061538 | Pride
Fxn Nb Immunoprecipitation Hek-293t 
GenomicsTranscriptional profiling of mouse embryonic fibroblasts harboring the Fxn G127V mutation
Transcriptional profiling of mouse embryonic fibroblasts harboring the Fxn G127V mutation
PRJNA1076569 | ENA
UnknownExpanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells.
Not available
S-EPMC4498154 | biostudies-literature
GenomicsTotal RNA sequencing of FXN knockdown or RNA editing gene knockdown in pulmonary artery endothelial cells
Total RNA sequencing of FXN knockdown or RNA editing gene knockdown in pulmonary artery endothelial cells
PRJNA720606 | ENA
GenomicsCorrection of splicing defect in compound heterozygous FRDA patient carrying FXN 165+5G>C point mutation.
Correction of splicing defect in compound heterozygous FRDA patient carrying FXN 165+5G>C point mutation.
PRJNA1093135 | ENA
UnknownFAST-1 antisense RNA epigenetically alters FXN expression.
Not available
S-EPMC6249312 | biostudies-literature
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