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ProteomicsExploring the interactome of human METTL9
Exploring the interactome of the human putative methyltransferase enzyme METTL9.
ORGANISM(S): Homo sapiens (Human) 
2020-11-19 | PXD016408 | Pride
Mettl9 Interactome 
ProteomicsCharacterization of HAP-1 METTL9 KO cells
LAbel free quantitation of HAP1 WT and METTL9 KO cells. METTL9 is a recently established human histidine specific methyltransferase.
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD023075 | Pride
Human Cell Lc-ms/ms 
ProteomicsThe methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3- methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-11-23 | PXD022067 | Pride
Metylation histidine mettl9 
ProteomicsProSeAM SILAC MS screening for METTL9 substrates
Click chemistry based substrates screening for METTL9 in Mettl9 KO MEF cells.
ORGANISM(S): Mus Musculus (mouse) 
2020-11-19 | PXD016823 | JPOST Repository
ProteomicsMETTL9 sustains vertebrate neural development primarily via non-catalytic functions
METTL9 is an enzyme catalysing histidine N1-methylation (1-MH). Given the high levels of this methyltransferase during vertebrate nervous system development, we dissected the roles of Mettl9 during this relevant physiological process. We generated three mouse embryonic stem cell lines featuring a co...
ORGANISM(S): Mus musculus (Mouse) Xenopus laevis (African clawed frog) 
2025-07-29 | PXD053437 | Pride
Mouse Mettl9 Proteome Golgi integrity 
GenomicsMETTL9 methylates H2B a-N-proline and suppresses human retrotransposition
The methylation of residues within histones plays a central role in regulating genome function; however, little is known about the biological importance of a-N-terminal histone methylation. Here we explored the function of the previously uncharacterized a-N methylation of mammalian histone 2B prolin...
ORGANISM(S): Homo sapiens 
2018-12-02 | GSE60176 | GEO
ProteomicsCharacterization of METTL9-mediated methylation of DNAJB12
The analysis is part of a study aimed at characterizing a new human histidine-specific methyltransferase denoted METTL9. The putative METTL9 substrate DNAJB12 was immunoprecipitated from HEK293 cells and its PTM status was assessed by LC-MSMS.
ORGANISM(S): Homo sapiens (Human) 
2020-11-19 | PXD020010 | Pride
Lc-msms Hek293 Methylation 
UnknownMETTL9 sustains vertebrate neural development primarily via non-catalytic functions.
Not available
S-EPMC12313917 | biostudies-literature
UnknownMETTL9-SLC7A11 axis promotes hepatocellular carcinoma progression through ferroptosis inhibition.
Not available
S-EPMC10684523 | biostudies-literature
UnknownThe methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
Not available
S-EPMC7873184 | biostudies-literature
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