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TranscriptomicsMicroarray analysis of BHLHB2 and BHLHB3 target genes in human skeletal muscle cells
In this study we have identified the target genes of BHLHB2 and BHLHB3 in primary cultures of human skeletal muscle cells using adenoviral vectors expressing either BHLHB2 or BHLHB3, and oligonucleotide microarrays. Human myotubes were prepared from 4 different skeletal muscle biopsies. After 7 day...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-12947 | biostudies-arrayexpress
TranscriptomicsFTO: gene expression and function in skeletal muscle
We identified the target genes of FTO ("fat mass and obesity associated") in primary cultures of human skeletal muscle cells using adenoviral vectors expressing FTO or GFP and oligonucleotide microarrays. Human myotubes were prepared from 4 different skeletal muscle biopsies. After differe...
ORGANISM(S): Homo sapiens 
2011-07-05 | E-GEOD-22857 | biostudies-arrayexpress
TranscriptomicsLoss of tight junction integrity induces loss of epithelial phenotype: case of Claudin11 knock out in testis.
Epithelium barrier integrity is assumed at least in part by the presence of junctions between cells. Tight-junction formation may be necessary for Sertoli cells to cease dividing and to support germ cell development. Microarray analysis of P20 Cldn11 +/- and Cldn11-/- testes confirmed the impact od ...
ORGANISM(S): Mus musculus 
2010-04-11 | E-GEOD-15492 | biostudies-arrayexpress
TranscriptomicsCharaterization of the initial molecular events of adipose tissue development and growth during overfeeding in humans
The adaptive mechanisms in response to excess energy supply are still poorly known in humans. Our aims were to define metabolic responses and changes in gene expression in adipose tissue of healthy volunteers during fat overfeeding. Healthy lean and overweight subjects were submitted to a high fat d...
ORGANISM(S): Homo sapiens 
2012-03-05 | E-GEOD-28005 | biostudies-arrayexpress
TranscriptomicsMicroarrays analysis of SREBP-1a and SREBP-1c target genes identify new regulatory pathways.
In this study we have identified the target genes of SREBP1a and SREBP1c in primary cultures of human skeletal muscle cells using adenoviral vectors expressing the mature nuclear form of human SREBP1a or SREBP1c combined with oligonucleotide microarrays. Keywords: comparison of human myotubes infec...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10918 | biostudies-arrayexpress
TranscriptomicsPersistent Organic Pollutants cause insulin resistance and ruin the health effects of salmon oil
Transcriptional profiling of Rat liver submitted to high fat diets made with either crude (HFC) or refined salmon oil (HFR). Keywords: transcriptomic analysis Two groups of rats were submitted to high fat diet containing either crude salmon oil (HFC) or refined salmon oil (HFR). After 28 days, liv...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-13716 | biostudies-arrayexpress
TranscriptomicsPolyphenols protection against fructose overload
To decipher the beneficial effects of Polyphenols on health, healthy volunteers were randomized into two groups and were submitted to either a red grape polyphenol rich extract supplemented diet (PP) or a placebo diet (PCB) during 8 weeks. Then they were submitted to a fructose load (3g/kg Fat Free ...
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-35764 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in peripheral blood cells of patients with rheumatoid arthitis in response of anti-TNF-alpha
The goal of this study was to characterize the effects of anti-TNF-alpha treatments on gene expression in peripheral blood mononuclear cells. 8 women were submitted to a 12 weeks treatments with Etanercept or Adalimumab. Peripheral blood mononuclear cells were taken before and after the treatment. ...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-12897 | biostudies-arrayexpress
TranscriptomicsGene regulation by full length human adiponectin
Transcriptionnal profiling of 4 human cell lines treated during 3 hours with human adiponectin Keywords: transcriptionnal analysis Four human cell lines (Hela, HepG2, Panc-1, Hek293) were grown until confluence. These cell lines were serum depleted during 2 hours and then treated with human adipone...
ORGANISM(S): Homo sapiens 
2010-12-09 | E-GEOD-14070 | biostudies-arrayexpress
TranscriptomicsTranscriptional signature of the developing rat testes and ovaries following embryonic exposure to 2,3,7,8-TCDD
We determined global gene changes in immature ovaries and testes in response to an in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Microarray analysis was performed using testes and ovaries of the dioxin-exposed dams’ offspring. One hundred and thirteen genes were differentially e...
ORGANISM(S): Rattus norvegicus 
2011-10-11 | E-GEOD-32890 | biostudies-arrayexpress
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