Sort   by:  
 Page size 
MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
TranscriptomicsProfiling downregulation of the mevalonate pathway in Staphylococcus aureus
Isoprenoids are a class of ubiquitous organic molecules synthesized from the five-carbon starter unit isopentenyl pyrophosphate (IPP). Comprising more than 30,000 known natural products, isoprenoids serve various important biological functions in many organisms. In bacteria, undecaprenyl pyrophospha...
ORGANISM(S): Staphylococcus aureus RN4220 
2010-05-05 | E-GEOD-13424 | biostudies-arrayexpress
TranscriptomicsMutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...
ORGANISM(S): Homo sapiens 
2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress
TranscriptomicsMevalonate pathway antagonist inhibits proliferation of serous tubal intraepithelial carcinoma and ovarian carcinoma in mouse models.
Statins are among the most frequently prescribed drugs because of their efficacy and low toxicity in treating hypercholesterolemia. Recently, statins have been reported to inhibit the proliferative activity of cancer cells, especially those with *TP53* mutations. Since *TP53* mutations occur in ...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-68986 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary HUVECs and an immortalized HUVEC cell line treated with atorvastatin and/or mevalonate
Rationale: Immortalized cells may exhibit important differences relative to their primary cell counterparts. Microarrays were used compare primary human umbilical vein endothelial cells (HUVECs) and the immortalized HUVEC cell line EA.hy926, in their response to inhibition of the mevalonate pathway ...
ORGANISM(S): Homo sapiens 
2007-08-21 | E-GEOD-2450 | biostudies-arrayexpress
GenomicsSingle cell RNA-seq analysis of PBMCs from mouse models of mevalonate kinase deficiency
Single cell RNA-seq analysis of PBMCs from mouse models of mevalonate kinase deficiency
PRJNA1269014 | ENA
ProteomicsMechanistic insight into the role of enzyme mevalonate kinase by a natural fatty acid -mediated killing of Leishmania donovani
We evaluated the anti-leishmanial efficacy of different saturated medium-chain fatty acids (FAs, C8-C18) where FA containing C8 chain, caprylic acid (CA), was found to be most potent against Leishmania donovani, the causative agent for visceral leishmaniasis (VL). Different analogs of CA with C8 cha...
ORGANISM(S): Leishmania donovani BPK282A1 
2022-10-14 | PXD034560 | Pride
Proteomics Ergosterol depletion Mevalonate kinase Competitive inhibition Caprylic acid Visceral leishmaniasis 
TranscriptomicsRole of mevalonate pathway intermediates in anticancer effect of statins
Simvastatin has been widely used for treatment of hypercholesterolemia due to its ability to inhibit HMG-CoA reductase, the rate limiting enzyme of de novo cholesterol synthesis via mevalonate pathway. Its inhibitory action causes also depletion of pathway intermediates, farnesyl pyrophosphate (FPP)...
ORGANISM(S): Homo sapiens 
2018-03-31 | E-MTAB-3263 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq analysis of PBMCs from mouse models of mevalonate kinase deficiency
The single cell RNA sequencing data here were used in the publication "NK cell dysfunction and interferon gamma production underlie autoinflammation in mevalonate kinase deficiency". This study sought to identify changes in immune cell populations in peripheral blood of MvkV377I/del91 mutant mice (a...
ORGANISM(S): Mus musculus 
2026-04-30 | GSE298361 | GEO
GenomicsMicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway [bulkRNA-seq]
MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway [bulkRNA-seq]
PRJNA885780 | ENA
Sort   by:  
 Page size