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MetabolomicsToxicometabolomics of the new psychoactive substances α-PBP and α-PEP studied in HepaRG cell incubates by means of untargeted metabolomics revealed unexpected amino acid adducts
Toxicometabolomics, essentially applying metabolomics to toxicology of endogenous compounds such as drugs of abuse or new psychoactive substances (NPS), can be investigated by using different in vitro models and dedicated metabolomics techniques to enhance the number of relevant findings. The presen...
2023-10-10 | MTBLS1481 | MetaboLights
MetabolomicsLiquid Chromatography-High-Resolution Mass Spectrometry-Based In Vitro Toxicometabolomics of the Synthetic Cathinones 4-MPD and 4-MEAP in Pooled Human Liver Microsomes
Synthetic cathinones belong to the most often seized new psychoactive substances on an international level. This study investigated the toxicometabolomics, particularly the in vitro metabolism of 2-(methylamino)-1-(4-methylphenyl)-1-pentanone (4-MPD) and 2-(ethylamino)-1-(4-methylphenyl)-1-pentanone...
2023-11-28 | MTBLS2218 | MetaboLights
MetabolomicsImpact of the used solvent on the reconstitution efficiency of evaporated biosamples for untargeted metabolomics studies

Introduction

Untargeted metabolomics intends to objectively analyze a wide variety of compounds. Their diverse physicochemical properties make it difficult to choose an appropriate reconstitution solvent after sample evaporation without influencing the chromatography or hamper column sorbent...
2021-10-27 | MTBLS1219 | MetaboLights
ModelsBegitt2014 - STAT1 cooperative DNA binding - double GAS polymer model
Begitt2014 - STAT1 cooperative DNA binding - double GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and modelling approaches. The authors have developed two ODE models to describe STAT1...
2024-09-02 | BIOMD0000000501 | BioModels
ModelsBegitt2014 - STAT1 cooperative DNA binding - single GAS polymer model
Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and modelling approaches. The authors have developed two ODE models to describe STAT1...
2024-09-02 | BIOMD0000000500 | BioModels
Manuscript Accepted 
TranscriptomicsEffect of TCPOBOP on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis
The nuclear receptor CAR (constitutive androstane receptor) mediates the effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) on gene transcription. To investigate the relative role of CAR and also PXR in the induction response, cDNA arrays were generated containing 120 (Sterolgene V1) ...
ORGANISM(S): Mus musculus 
2008-08-23 | E-GEOD-12509 | biostudies-arrayexpress
TranscriptomicsPhenobarbital and TCPOBOP effects on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis
This SuperSeries is composed of the following subset Series: GSE12489: Effect of phenobarbital on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis GSE12509: Effect of TCPOBOP on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis Ref...
ORGANISM(S): Mus musculus 
2008-08-23 | E-GEOD-12529 | biostudies-arrayexpress
TranscriptomicsEffect of PCN on CAR and PXR regulated genes involved in circadian rhythm, drug metabolism and cholesterol homeostasis
The nuclear receptor PXR (Pregnane X rreceptor) mediates the effects of pregnenolone-16alpha-carbonitrile (PCN) on gene transcription. The relative role of PXR and also CAR to the induction response by PCN was studied on cDNA arrays containing 320 (Steroltalk V2) genes (genes involved in cyrcadian r...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-12537 | biostudies-arrayexpress
TranscriptomicsEffect of phenobarbital on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis
The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital (PB) on gene transcription. To investigate the relative role of CAR and PXR in the induction response, cDNA arrays were generated containing 120 genes which are known to b...
ORGANISM(S): Mus musculus 
2008-08-23 | E-GEOD-12489 | biostudies-arrayexpress
ProteomicsAnalysis of UCHL1 knockout in brain
We analyzed the brain of 5 day old mice with homozygous and heterozygous brain specific UCHL1 knockout using nLC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2019-04-02 | PXD010449 | Pride
Uchl Brain Dub 
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