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TranscriptomicsResponse of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different, necessitating the direct study of low dose responses. Most such studies have utilized 2-dimensional culture systems, which may not fully represent responses in 3-dimensional tissue...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-16935 | biostudies-arrayexpress
TranscriptomicsBystander response to low dose (0.5 Gy) of alpha-particles in a human 3-dimensional skin model at 4h post-irradiation
Ionizing radiation (IR) not only affects cells that are directly irradiated but also their non-irradiated neighbors, which show responses known as bystander effects. While bystander and direct responses have several common end points including apoptosis and micronucleation, chromatin remodeling and ...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-23804 | biostudies-arrayexpress
TranscriptomicsBystander response to 0.5 Gy of alpha-particles in a human 3-dimensional skin model in 16h after exposure to ionizing radiation
Ionizing radiation (IR) not only affects cells that are directly irradiated but also their non-irradiated neighbors, which show responses known as bystander effects. While bystander and direct responses have several common end points including apoptosis and micronucleation, chromatin remodeling and ...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-23899 | biostudies-arrayexpress
TranscriptomicsBiological response to low dose of alpha-particles in a human 3-dimensional skin model, in 1 and 16h after exposure to ionizing radiation.
Direct irradiation of 3-dimensional skin model, Epi-200, with alpha-particles led to differential regulation of 166 genes: 16 and 150 genes were differentially expressed at 1 and 16 h postirradiation. Unlike the traditional 2-dimensional in vitro systems, Epi-200 made of the primary cells, epidermal...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-23901 | biostudies-arrayexpress
TranscriptomicsBystander responses to 0.5Gy of alpha-particles in a human 3-dimensional skin model in 4h after exposure to ionizing radiation
Direct irradiation of 3-dimensional skin model, Epi-200, with alpha-particles led to differential regulation of 545 genes at 4 h postirradiation. Unlike the traditional 2-dimensional in vitro systems, Epi-200 made of the primary cells, epidermal human keratinocytes. It mimics the structure of the hu...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-23903 | biostudies-arrayexpress
TranscriptomicsBystander response to 2.5 Gy of protons in a human 3-dimensional skin model in 16 h after exposure
Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling. Thus, identification and characterization of bystander mechanisms will help to development of new treatments of patients with a radiati...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-23803 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression responses to low doses of protons in a human 3-dimensional skin model
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different, necessitating the direct study of low dose responses. Most such studies have utilized 2-dimensional culture systems, which may not fully represent responses in 3-dimensional tissue...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20629 | biostudies-arrayexpress
TranscriptomicsBiological response to 2.5 Gy of X-rays in 3-dimensional skin model, Epi-200.
Biological response X-rays traditionally serves as a standard in comparative analysis of different qualities of ionizing radiation. Most such studies have utilized 2-dimensional culture systems, which may not fully represent responses in 3-dimensional tissues. To gain insight into biological respons...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-23807 | biostudies-arrayexpress
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