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ProteomicsGlobal proteogenomic analysis of human MHC I peptides derived from noncanonical reading frames
Using highthroughput mass spectrometry, we probed the sixreadingframe translation of human B cells’ transcriptome. We report that about 10% of MHC Iassociated peptides (MAPs) derive from noncanonical reading frames. These socalled cryptic MAPs originate from allegedly non- coding genomic sequences ...
ORGANISM(S): Homo sapiens (Human) 
2016-01-28 | PXD001898 | Pride
Proteogenomic cryptic mhc lc-msms maps 
TranscriptomicsTranscripts coding MHC I-associated peptides are enriched in microRNA-binding sites
MHC I-peptides (MIPs) play an essential role in normal homeostasis and diverse pathological conditions. MIPs derive mainly from defective ribosomal products (DRiPs), a subset of nascent proteins that fail to achieve a proper conformation and whose physical nature remains elusive. We used high-throug...
ORGANISM(S): Homo sapiens 
2012-03-25 | E-GEOD-35319 | biostudies-arrayexpress
ProteomicsViral immune evasions differentially impact cell surface presentation of MHC I allomorphs already at the peptide-loading complex
The transporter associated with antigen processing (TAP) translocates peptides from the cytosol into the endoplasmic reticulum (ER) where they are loaded onto major histocompatibility class I (MHC I) molecules. Stable peptide-MHC I complexes travel to the cell surface and present their antigenic car...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027408 | Pride
Er quality control Major histocompatibility complex class i Mass spectrometry Mhc i biogenesis Viral immune evasion Peptide-loading complex 
GenomicsPIKfyve inhibition upregulates surface expression of MHC class I to enhance immune responses in cancer
PIKfyve inhibition upregulates surface expression of MHC class I to enhance immune responses in cancer
PRJNA988072 | ENA
TranscriptomicsPIKfyve inhibition upregulates surface expression of MHC class I to enhance immune responses in cancer
Despite the remarkable clinical success of immunotherapies in a subset of cancer patients, many fail to respond to treatment and exhibit primary resistance. Here, we found thatgenetic or pharmacologic inhibitionof the lipid kinase PIKfyve, a regulator of autophagic flux and lysosomal biogenesis,upre...
ORGANISM(S): Mus musculus 
2023-11-13 | GSE235945 | GEO
GenomicsMHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements
MHC I-peptides (MIPs) play an essential role in normal homeostasis and diverse pathological conditions. MIPs derive mainly from defective ribosomal products (DRiPs), a subset of nascent proteins that fail to achieve a proper conformation and whose physical nature remains elusive. We used high-throug...
ORGANISM(S): Homo sapiens 
2012-03-25 | GSE35319 | GEO
UnknownDiacylglycerol kinase α regulates tubular recycling endosome biogenesis and major histocompatibility complex class I recycling.
Not available
S-EPMC4231670 | biostudies-literature
UnknownTargeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy.
Not available
S-EPMC10710078 | biostudies-literature
UnknownLTO1 and YAE1 regulate MHC-I expression via nonsense-mediated RNA decay in tumor cells.
Not available
S-EPMC12458808 | biostudies-literature
UnknownGlobal proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.
Not available
S-EPMC4728431 | biostudies-literature
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