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TranscriptomicsTranscription profiling of mouse RAG1 knockout CD4+ T cells to investigate the effect of absence of interaction with MHC class II on memory CD4 T cells
Effect of absence of interaction with MHC class II on memory CD4 T cells
ORGANISM(S): Mus musculus 
2007-03-01 | E-MEXP-890 | biostudies-arrayexpress
ProteomicsHLA-DO Modulates the Diversity of the MHC-II Self-peptidome
HLA-DR1 bound peptides of five biological replicates of LG2-WT(012916_WT1,022216_WT1, 02080316MHCIIWT1, 080316MHCIIWT2, 080316MHCIIWT3) and DO-KO Clone 1 LG-2 cells (012916_KO1, 022216_DO1, 081216MHCIIKO1, 080416MHCIIKO2, 080416MHCIIKO3) were processed in parallel. Each biological replicate has 3 te...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-03 | MSV000082570 | MassIVE
TranscriptomicsEffect of MHC II expression in pro-B cells: Pre-B cells and follicular B cells from wild-type and MHC II conditional mice
Hardy’s Fraction D bone marrow pre-B cells and splenic follicular B cells were purified by flow cytometry according to MHC II expression from wild-type and ItgaxcreH2-Ab1c MHC II conditional mice and transcriptionally profiled by RNA-seq. Duplicate or triplicate samples for each genotype and level o...
ORGANISM(S): Mus musculus 
2018-08-07 | E-MTAB-6765 | biostudies-arrayexpress
ProteomicsMHC class I ligandome of cells treated with palladium
MHC class I ligandome analysis of mouse dendritic cells treated with palladium
ORGANISM(S): Mus Musculus (mouse) 
2021-12-16 | PXD028795 | JPOST Repository
TranscriptomicsEffect of MHC II expression in pro-B cells: F6 leukaemic cell line
F6 murine leukaemic cells were transfected either with MHC II or with GFP and transcriptionally profiled by RNA-seq. Triplicate samples for each genotype were sequenced. This is part of ongoing investigation of a possible cell-intrinsic role of MHC II B cells.
ORGANISM(S): Mus musculus 
2018-08-07 | E-MTAB-6763 | biostudies-arrayexpress
ProteomicsIsolation of mouse and human MHC class I- and II-associated peptides for the analysis of immunopeptidomes by mass spectrometry
Immunopeptidomics is an emerging field that fuels and guides the development of vaccines and immunotherapies. More specifically, it refers to the science of investigating the composition of peptides presented by major histocompatibility complex (MHC) class I and class II molecules using mass spectro...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-12-07 | PXD028633 | Pride
Mhc class i associated peptides Mass spectrometry Human Immunopeptidome Mhc class ii associated peptides Mouse 
TranscriptomicsComplete Haplotype Phasing of the MHC and KIR Loci with Targeted HaploSeq
Rapid advances in biochemical technologies have enabled several strategies for typing candidate HLA alleles, but linking them into a single MHC haplotype structure remains challenging. Here we have developed a multi-loci haplotype phasing technique and demonstrate its utility towards phasing of MHC ...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-GEOD-65726 | biostudies-arrayexpress
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-19 | MSV000084980 | MassIVE
ProteomicsQuantitative Measurement of the Requirement of Diverse Protein Degradation Pathways in MHC Class I Peptide Presentation
The adaptive immune system distinguishes self from non-self by surveying peptides generated from degradation of intracellular proteins that are loaded onto MHC Class I molecules for display on the cell surface. While early studies reported that the bulk of cell surface MHC Class I complexes require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-15 | MSV000091285 | MassIVE
ProteomicsImmunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design
No currently licensed vaccine reliably prevents pulmonary tuberculosis, a leading cause of infectious disease mortality with a growing rate of extensive drug resistance. Developing effective new vaccines will likely require identifying Mycobacterium tuberculosis (Mtb)-derived antigens presented on M...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD055952 | Pride
Dendritic cells Tuberculosis Mhc class ii Human Immunopeptidomics 
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