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ProteomicsEnabling Routine MHC-II Associated Peptide ProteomicS (MAPPs) for Risk Assessment of Drug-Induced Immunogenicity
The appended raw files, csv files and other documents were deposited in the public domain in support for the publication Enabling Routine MHC-II Associated Peptide ProteomicS (MAPPs) for Risk Assessment of Drug-Induced Immunogenicity Guido Steiner, Celine Marban-Doran, Jessica Langer, Tatiana Pimeno...
ORGANISM(S): Custom Antibody Sequences Homo Sapiens (ncbitaxon:9606) 
2020-05-05 | MSV000085375 | MassIVE
ProteomicsRational engineering of minimally immunogenic nucleases for gene therapy
Genome editing using CRISPR-Cas systems is a promising avenue for the treatment of genetic diseases. However, cellular and humoral immunogenicity of genome editing tools, which originate from bacteria, complicates their clinical use. Here we report reduced immunogenicity (Red)(i)-variants of two cli...
ORGANISM(S): Homo sapiens (Human) 
2024-11-07 | PXD054579 | Pride
Sacas9 Mapps Ascas12a Gene therapy 
ProteomicsExpanding the MAPPs assay to accommodate MHC-II pan re-ceptors for improved predictability of potential T cell epitopes
The appended raw files, csv files and other documents were deposited in the public domain in support for the publication "Expanding the MAPPs assay to accommodate MHC-II pan re-ceptors for improved predictability of potential T cell epitopes" by Katharina Hartman, Guido Steiner, Michel Siegel, Cary ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-25 | MSV000092747 | MassIVE
UnknownMHC-associated peptide proteomics enabling highly sensitive detection of immunogenic sequences for the development of therapeutic antibodies with low immunogenicity.
Not available
S-EPMC6284561 | biostudies-literature
UnknownThe MHC Associated Peptide Proteomics assay is a useful tool for the non-clinical assessment of immunogenicity.
Not available
S-EPMC10616951 | biostudies-literature
ProteomicsHLA-DR MAPPs Assay in moDCs From 8 Donors Loaded With Infliximab
MHC-associated peptide proteomics (MAPPs) enables direct identification of peptides naturally processed and presented by APCs, providing experimental evidence for antigen processing and HLA class II presentation. In this dataset published in PMID: 41085630, an HLA-DR–focused MAPPs workflow was used ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD074155 | Pride
UnknownApplying MAPPs Assays to Assess Drug Immunogenicity.
Not available
S-EPMC7186346 | biostudies-literature
UnknownAssessing MAPPs assay as a tool to predict the immunogenicity potential of protein therapeutics.
Not available
S-EPMC10576005 | biostudies-literature
UnknownExpanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes.
Not available
S-EPMC10525474 | biostudies-literature
ProteomicsHLA class I MAPPs Assay in 10 mono-allelic cell lines transfected with SaCas9, AsCas12a and CasΦ
MHC-associated peptide proteomics (MAPPs) enables direct identification of intracellular peptides naturally processed and presented by cells, providing experimental evidence for antigen processing and HLA class I presentation. In this dataset an HLA-A/B/C-focused MAPPs workflow was used on 10 mono-a...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD073207 | Pride
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