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ProteomicsCross-linking of the human MHC-I peptide-loading complex
The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum (ER), essential for establishing a hierarchical immune response. The PLC coordinates peptide translocation into the ER with loading and editing of major histocompatibility complex class I mol...
ORGANISM(S): Homo sapiens (Human) 
2017-11-07 | PXD007928 | Pride
Cross-linking Cryo-electron microscopy Structure Mhc-i peptide-loading complex 
ProteomicsViral immune evasions differentially impact cell surface presentation of MHC I allomorphs already at the peptide-loading complex
The transporter associated with antigen processing (TAP) translocates peptides from the cytosol into the endoplasmic reticulum (ER) where they are loaded onto major histocompatibility class I (MHC I) molecules. Stable peptide-MHC I complexes travel to the cell surface and present their antigenic car...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027408 | Pride
Er quality control Major histocompatibility complex class i Mass spectrometry Mhc i biogenesis Viral immune evasion Peptide-loading complex 
ProteomicsMHC class I ligandome of cells treated with palladium
MHC class I ligandome analysis of mouse dendritic cells treated with palladium
ORGANISM(S): Mus Musculus (mouse) 
2021-12-16 | PXD028795 | JPOST Repository
UnknownMolecular basis of MHC I quality control in the peptide loading complex.
Not available
S-EPMC9365787 | biostudies-literature
UnknownAtomistic structure and dynamics of the human MHC-I peptide-loading complex.
Not available
S-EPMC7456110 | biostudies-literature
UnknownLight control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking.
Not available
S-EPMC8010092 | biostudies-literature
ProteomicsTapasin assembly surveillance by the RNF185/MBRL ubiquitin ligase complex regulates MHC-I antigen presentation
Immune surveillance by cytotoxic T cells eliminates tumor cells and cells infected by intracellular pathogens. This process relies on the presentation of antigenic peptides on Major Histocompatibility Complex class I (MHC-I) at the cell surface. The loading of these peptides onto MHC-I depends on t...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-09-17 | PXD048728 | Pride
Rnf185 mbrl tapasin 
UnknownDual role of the peptide-loading complex as proofreader and limiter of MHC-I presentation.
Not available
S-EPMC11145271 | biostudies-literature
UnknownArchitectural principles of transporter-chaperone coupling within the native MHC I peptide-loading complex.
Not available
S-EPMC12758552 | biostudies-literature
UnknownDynamic interactome of the MHC I peptide loading complex in human dendritic cells.
Not available
S-EPMC10288655 | biostudies-literature
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