Long non-coding RNAs (lncRNAs) are emerging regulators of genomic stability and human disease. However, the molecular mechanisms by which nuclear lncRNAs directly contribute to DNA damage responses remain largely unknown. Using RNA antisense purification coupled with quantitative mass spectrometry (...
Antifungal resistance, particularly the rise in multidrug resistance, has become a critical public health concern, garnering substantial attention. In this study, we used experimental evolution with Neurospora crassa as a model and identified a novel multidrug-resistance gene, msp-8, which encodes a...
In this project, we affinity-purified FLAG-ZDHHC5 from HEK293T cells co-expressing MYR-HA-AKT and subjected to mass spectrometry analysis. Three phosphopeptides derived from ZDHHC5 were identified.
Protein methylation plays important roles in DNA damage signaling. To date, there is still a lack of global profiling of whole-cell methylation changes during the DNA damage response and repair. In this study, using HILIC affinity enrichment combined with MS analysis, we conducted a quantitative ana...
