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MetabolomicsUPLC-QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis
Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma l...
2021-10-18 | MTBLS1183 | MetaboLights
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
ProteomicsProteomic Analysis on the Mechanism of Iron-Compensation Substitute for Manganese Deficiency of Streptococcus pneumoniae
Iron (Fe) and Manganese (Mn) are essential for bacterial survival and virulence as they are involved in catalysis, infection and biofilm formation. The basal metabolism of pathogenic bacteria would be disturbed by the deficiency of metal ions in the host environment. In this study, we found that Str...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2023-09-30 | PXD008652 | Pride
Manganese deficiency Iron-compensation Proteomic Streptococcus pneumoniae 
ProteomicsThe analysis of the α2,6-sialylated proteins in endometrium from porcine gestational day 15 by LC-MS/MS
Implantation is the attachment of embryo in the endometrium. Failure in implantation is a major cause of early pregnancy loss. During implantation, the temporal uterine lumen closure can help embryo attach to the uterus. In pigs, extending of endometrial folds to form interlocking finger-like projec...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-02-17 | PXD027571 | Pride
Porcine pregnancy Α2 6-sialylated proteins Endometrium Lc-ms/ms 
TranscriptomicsTargeted disruption of Hotair leads to homeotic transformation and de-repression of imprinted genes [Microarray Analysis]
Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here we show that targeted deletion of mouse Hotair lncRNA leads to de-repression of hundreds of genes, resulting in homeotic transformatio...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-48004 | biostudies-arrayexpress
GenomicsTargeted disruption of Hotair leads to homeotic transformation and de-repression of imprinted genes [RNA-Seq, ChIP-Seq]
Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here we show that targeted deletion of mouse Hotair lncRNA leads to de-repression of hundreds of genes, resulting in homeotic transformatio...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-48005 | biostudies-arrayexpress
Proteomicscomparative proteomics in schistosoma japonicum
In this study, isobaric tags for relative and absolute quantification (iTRAQ) were used to identify differential expression proteins (DEPs) of adult schistosomes across two different intermediate host development: Oncomelania hupensis (O.hupensis) and Oncomelania weishan (O.weishan).
ORGANISM(S): Schistosomatidae Sp. W829 Schistosomatidae Sp. W688 
2022-10-24 | PXD035090 |
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