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TranscriptomicsTranscription profiling of thymus from ovariectomized mice to compare the effects of estrogen and its analog genistein on thymus.
Compared the effects of Estrogen and its analog Genistein on mouse thymus. Endogenous estrogen were minimized by removal of ovaries. Samples were collected at 4 time points: 0 days, 2 days, 3 days and 6 days from the start of the treatment. Two biological replicates at each time point. Experiment Ov...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2889 | biostudies-arrayexpress
TranscriptomicsEgress of mature murine regulatory T cells from the thymus requires RelA
The mechanism of egress of mature regulatory T cells (Tregs) from the thymus to the periphery remains enigmatic, as does the nature of those factors expressed in the thymic environment. Here, we examined the fate of thymic Tregs in TNFα/RelA double-knockout (TA-KO) mice, because TA-KO mice retain a...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-64191 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of TMT in the thymus of nine mice
To evaluate the effects of GLSO on protein expression levels in immunocompromised mics, 2-3 biological replicates of the thymus sample were pooled and labeled one unit of TMT reagent, resulting in the creation of a 9-channel (3 biological pooled replicates in each group) TMT-base proteome.
ORGANISM(S): Mus musculus (Mouse) 
2026-02-05 | PXD067907 | Pride
Mice thymus  tmt 
Proteomics“Identifying the SLC25A46 interactome in transgenic mice: Thymus"
SLC25A46 is an outer mitochondrial protein, member of the mitochondrial carrier family (SLC25), whereas mutations result in mitochondrial structure abnormalities leading to a wide spectrum of neurological disorders. SLC25A46 is known to interact with members of the MICOS (Mitochondrial Contact Site)...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-11 | PXD027603 | Pride
Thymus Mitochondria Mouse Slc25a46 Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse thymus from ZAS3-null vs wild-type
The HIVEP/ZAS/Schnurri genes encode large zinc finger proteins that regulate gene expression through DNA binding to the kappaB motif. The ZAS proteins have also been shown to associate with signaling molecules to regulate the TNFa and TGFb signaling pathways. Because ZAS3 transcript and protein expr...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6570 | biostudies-arrayexpress
ProteomicsProteomic identification of MHC class I-associated peptidome derived from non-obese diabetic mouse thymus and pancreas
The peptides repertoire presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules, referred to as the MHC I-associated peptidome (MIP), regulates all critical events that occur during the lifetime of CD8+ T cells. The MIP presented by thymic antigen presenting cells (APCs...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031966 | Pride
Pancreas Lc-ms/ ms Nod mouse Mhc class i-associated peptidome T1d Cd8+ t-cell. Thymus 
TranscriptomicsTranscription profiling of mouse PKBalpha-/-thymus reveals deletion of PKBalpha/Akt1 affects thymic development
The thymus constitutes the primary lymphoid organ for the majority of T cells. The phosphatidyl-inositol 3 kinase (PI3K) signaling pathway is involved in lymphoid development. Defects in single components of this pathway prevent thymocytes from progressing beyond early T cell developmental stages. P...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7875 | biostudies-arrayexpress
Proteomicsthymus mouse LC-MSMS - Thymic Microenvironment Is Modified by Malnutrition and Leishmania infantum Infection
The thymus is one of the most affected organs during malnutrition, exhibiting atrophy and thymocyte depletion, characteristics that are also observed in several infectious diseases. The detrimental effects of malnutrition on immune responses to pathogens have long been recognized and it is considere...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010414 | Pride
Lc-msms Fluid Malnutrition Mouse Thymus 
TranscriptomicsMessenger RNA expression profile of medullary thymic epithelial-mTEC-cells by in vivo thymus Aire knockdown-BALB-c mice
Small interfering RNA (siRNA) was used to knockdown Autoimmune regulator(Aire) gene by in vivo electroporation of the thymus of BALB-c mice. In This set of data we include control and Aire-silenced mTEC cells isolated from thymus of BALB-c mice.
ORGANISM(S): Mus musculus 
2012-08-11 | E-MEXP-3343 | biostudies-arrayexpress
TranscriptomicsRole of AhR in thymocyte emigration in vivo
Over-activation of the aryl hydrocarbon receptor by TCDD in mice leads among other phenotypes to a severe thymic atrophy accompanied by immunosuppression. TCDD causes a block in thymocyte maturation and a preferential emigration of immature CD4-CD8- DN thymocytes (recent thymic emigrants) into the p...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-10166 | biostudies-arrayexpress
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