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TranscriptomicsTranscription profiling of mouse livers from growth hormone receptor (GHR) deficient mice and mice expressing different forms of truncated GHR to study the GHR signaling domains and their associated transcripts.
Total RNA was extracted from mouse liver samples using an Ambion RNaqueous RNA extraction kit. Targets were produced using modified Affymetrix procedure from 5ug of total RNA. 3 biological replicates were analysed per each group of animals.
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-988 | biostudies-arrayexpress
MetabolomicsIntegrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism

OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular changes upon lack of OCIAD1, we used mass spectrometry to st...

2025-04-25 | MTBLS12329 | MetaboLights
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
UnknownRandomized Phase III Trial of Adjuvant Pazopanib Versus Placebo After Nephrectomy in Patients With Localized or Locally Advanced Renal Cell Carcinoma.
Not available
S-EPMC6018511 | biostudies-literature
TranscriptomicsTranscription profiling of mouse WT and Cav-3 knockouts on FVB/N genetic background mammary glands reveals loss of caveolin-3 induces the development of a lactogenic microenvironment
Here, we show that functional loss of a single gene is sufficient to confer constitutive milk protein production and protection against mammary tumor formation. Caveolin-3 (Cav-3), a muscle-specific caveolin-related gene, is highly expressed in striated and smooth muscle cells. We demonstrate that C...
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-12881 | biostudies-arrayexpress
TranscriptomicsKdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary in Aspergillus nidulans metabolism
A. nidulans kdmA encodes a member of the KDM4 family of jumonji histone demethylase proteins, highly similar to metazoan orthologues both within functional domains and in domain architecture. This family of proteins exhibits demethylase activity toward lysines 9 and 36 of histone H3 and plays a prom...
ORGANISM(S): Aspergillus nidulans 
2014-11-26 | E-GEOD-63672 | biostudies-arrayexpress
TranscriptomicsExpression data MCF10A/ErbB2 RB-proficient and RB-deficient cells cultured in 3-D cell culture
Gene expression analysis for structural components in Rb-deficient and RB-proficient ErbB2-overexpressing immortalized breast cell line using 3-D cell culture model to analyze structural and organizational changes of epithelial cells. Cells were cultured in a reconstituted membrane for 7 days. Cells...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-36425 | biostudies-arrayexpress
UnknownSTIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons
Not available
S-SCDT-10_15252-EMBJ_2022111372 | biostudies-other
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