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TranscriptomicsTranscription profiling by array of human dendritic cells after Poly(I:C)-based or PGE2-based maturation
Generation of human monocyte-derived DCs Peripheral blood mononuclear cells (PBMC) were isolated by Ficoll density centrifugation from buffy coats or whole blood of healthy donors and resuspended in serum-free medium (CellGro, CellGenix GmbH, Freiburg, Germany), supplemented with penicillin (50U/ml)...
ORGANISM(S): Homo sapiens 
2008-11-01 | E-MEXP-1230 | biostudies-arrayexpress
GenomicsCooperative binding of DNA sequence non-specific HMGbox Factor Ubf and TBP-TAF complex SL1 determines RNA Polymerase I promoter recognition in vivo and its dysfunction underlies the Ubf-E210K neuroregression syndrome
Transcription of the >200 rRNA genes (rDNA) by RNA Polymerase I (RPI) determines as much as 35% of total nuclear RNA synthesis and is a major determinant of cell growth implicated in a range of hypertrophic and developmental disorders. Activation of the rDNA involves the formation of an extended nuc...
ORGANISM(S): Mus musculus 
2022-02-03 | E-MTAB-11385 | biostudies-arrayexpress
UnknownExpression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis.
Not available
S-EPMC5322979 | biostudies-literature
UnknownInhibition of Glyoxalase-I Leads to Reduced Proliferation, Migration and Colony Formation, and Enhanced Susceptibility to Sorafenib in Hepatocellular Carcinoma.
Not available
S-EPMC6710403 | biostudies-literature
TranscriptomicsCooperative binding of DNA sequence non-specific HMGbox Factor Ubf and TBP-TAF complex SL1 determines RNA Polymerase I promoter recognition in vivo and its dysfunction underlies the Ubf-E210K neuroregression syndrome
Transcription of the >200 rRNA genes (rDNA) by RNA Polymerase I (RPI) determines as much as 35% of total nuclear RNA synthesis and is a major determinant of cell growth implicated in a range of hypertrophic and developmental disorders. Activation of the rDNA involves the formation of an extended nuc...
ORGANISM(S): Mus musculus 
2021-08-31 | E-MTAB-10433 | biostudies-arrayexpress
ModelsLavoie2020 - F.cylindrus_Genome_scale_model
This is an automatically generated .xml file describing a genome-scale model of the metabolism of a polar diatom, Fragilariopsis cylindrus. This reconstruction has been used for an in-depth study of metabolic robustness, which has been recently submitted for publication by Lavoie et al. (2020) in th...
2021-01-18 | MODEL2001280001 | BioModels
UnknownTranscription elongation by RNA polymerase I is linked to efficient rRNA processing and ribosome assembly.
Not available
S-EPMC1927085 | biostudies-literature
GenomicsDeconvolution ChIP-seq profiling of UBF and RPA194 in K562 cells to identify analogous enhancer structures on mouse and human ribosomal RNA genes
The combination of Chromatin Immunoprecipitation and Massively Parallel Sequencing, or ChIP-Seq, has greatly advanced our genome-wide understanding of chromatin and enhancer structures. However, its resolution at any given genetic locus is limited by several factors. In applying ChIP-Seq to study th...
ORGANISM(S): Homo sapiens 
2017-12-31 | E-MTAB-6032 | biostudies-arrayexpress
UnknownIFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation.
Not available
S-EPMC9354889 | biostudies-literature
TranscriptomicsNF1 microdeletions characterization by custom high-resolution array CGH
To allow accute charaterization of NF1 locus constitutional microdeletion in 70 NF1 patients, a custom array CGH was developped. Goal was to obtain genomic rearrangements fine characterization in order to perform genotype-phenotype correlation in NF1 microdeleted patients. To serve as a reference g...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-19730 | biostudies-arrayexpress
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