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TranscriptomicsCyclin K and cyclin D1b are oncogenic in myeloma cells
To study the oncogenic potential of cyclin D1b in the context of mature B cells we generated several cell clones derived from LP-1 MM cell line expressing either cyclin D1b, Myc or cyclin K oncogenes. Transcriptomic analysis allowed us to describe several mechanisms of cyclin D1b- and K-mediated onc...
ORGANISM(S): Homo sapiens 
2010-04-23 | E-GEOD-15497 | biostudies-arrayexpress
ProteomicsTEAD inhibitor K-975 enhances KRASG12C inhibitor adagrasib-mediated cancer cell proliferation inhibition via dual cell cycle arrest
Here we investigate the effect of the dual inhibition, in KRASG12C mutated NSCLC cells, using the KRASG12Ci adagrasib (MRTX849) and the pan-TEAD inhibitor (TEADi) K-975. We show that K-975 enhances adagrasib-induced tumor cell growth inhibition in cancer cells. Mechanistically, we detect a downregul...
ORGANISM(S): Homo Sapiens (human) 
2023-05-12 | PXD039726 | JPOST Repository
TranscriptomicsIdentification of potassium and chloride channels in eccrine sweat glands
K and Cl channels play critical role for sweat secretion, however, individual K or Cl channels and their functions are largely unknown. By comparing expreession profilings between wild-type and Eda mutant Tabby footpads we identified 4 K and 2 Cl channels highly expressed in mouse eccrine sweat glan...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-73715 | biostudies-arrayexpress
UnknownStage-Specific Changes in the Water, Na+, Cl- and K+ Contents of Organelles during Apoptosis, Demonstrated by a Targeted Cryo Correlative Analytical Approach.
Not available
S-EPMC4807926 | biostudies-literature
TranscriptomicsFoxA1 regulates sweat secretion through Best2 and Nkcc1 ion transporters
Body temperature is maintained in a narrow range in mammals, primarily controlled by sweating. In humans, the dynamic thermoregulatory organ, comprised of 2-4 million sweat glands distributed over the body, can secrete up to 4 liters of sweat per day1, thereby making it possible to withstand high te...
ORGANISM(S): Mus musculus 
2012-01-11 | E-GEOD-32347 | biostudies-arrayexpress
UnknownForkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1.
Not available
S-EPMC3268268 | biostudies-literature
TranscriptomicsTranscription profiling of Synechococcus elongatus wild type, K10 and MuD mutants growth with or without Fe
Synechococcus elongatus PCC7942 wild type, the IdiB-free S.elongatus mutant K10 (Michel et al. 1999; Microbiology, 145: page 1473-1484) and the IdiC-merodiploid mutant MuD (Pietsch et al. 2007, Photosynth. Res. 94: page 91-108) were cultivated in BG11 medium, continuously bubbled with 2%CO2-enriched...
ORGANISM(S): Synechococcus elongatus 
2008-07-13 | E-MEXP-1657 | biostudies-arrayexpress
ProteomicsQuantifying Competition Among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism
Mitochondrial dysfunction is one of many key factors in the etiology of alcoholic liver disease (ALD). Lysine acetylation is known to regulate numerous mitochondrial metabolic pathways and recent reports demonstrate that alcohol-induced protein acylation negatively impacts these processes. To identi...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-23 | PXD012089 | Pride
Ethanol metabolism Succinylation Mitochondira Acetylation Acylation 
UnknownRivaroxaban vs Vitamin K Antagonist in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease.
Not available
S-EPMC11198259 | biostudies-literature
TranscriptomicsExpression profiling of hemocytes from Anopheles gambiae after malaria parasite infection
Insect hemocytes mediate important cellular immune responses including phagocytosis and encapsulation, and also secrete immune factors such as opsonins, melanization factors, and antimicrobial peptides. In Anopheles, they contribute to the defense against malaria parasite invasion during the early s...
ORGANISM(S): Anopheles gambiae 
2009-10-29 | E-GEOD-17866 | biostudies-arrayexpress
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