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ProteomicsSimultaneous chemical proteomics of Nuclear, mitochondira and ER
The endoplasmic reticulum (ER) is an organelle that performs a variety of essential cellular functions via interactions with other organelles. Despite its important role, chemical tools for profiling the composition and dynamics of ER proteins remain very limited because of the labile nature of thes...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011501 | Pride
Hela cell Chemical proteomics Mitochondria Er Nuclear 
TranscriptomicsIntercellular nanotube-mediated mitochondrial transfer enhances T-cell metabolic fitness and antitumor efficacy
Mitochondrial loss and dysfunction drive T cell exhaustion and represent major barriers to successful T cell immunotherapies. We found that mesenchymal stromal cells (MSC) establish nanotubular connections with T cells in a TLN2-dependent manner and leveraged these intercellular highways to supply n...
ORGANISM(S): Mus musculus 
2024-09-13 | GSE229487 | GEO
UnknownUbiquitylation of cyclin C by HACE1 regulates cisplatin-associated sensitivity in gastric cancer.
Not available
S-EPMC8958351 | biostudies-literature
UnknownHydrophobic profiles of the tail anchors in SLMAP dictate subcellular targeting.
Not available
S-EPMC2712456 | biostudies-literature
ProteomicsYBEY is an essential biogenesis factor for mitochondrial ribosomes
The aim was to evaluate the protein composition of human mitoribosomes in YBEY knockout cells. We compared the parental cell line HEK293T-REx with the YBEY knockout cells HEK293T-RExΔYBEY.
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD015310 | Pride
Ribosomes Mitochondira 
ProteomicsArabidopsis Mitochondria Proteomics Probing GatCAB-dependent mistranslation
Protein translation is a fundamental principle in cell biology. It requires transfer RNAs (tRNAs) loaded with their cognate amino acid to ensure the accurate incorporation of amino acid into the nascent peptide chain. Bacteria, mitochondria, and plastids synthesize glutaminyl -tRNAs (Gln-tRNAGln) fo...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-06-08 | PXD057451 | Pride
Mitochondira Mistranslation Gatcab Dda 
ProteomicsQuantifying Competition Among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism
Mitochondrial dysfunction is one of many key factors in the etiology of alcoholic liver disease (ALD). Lysine acetylation is known to regulate numerous mitochondrial metabolic pathways and recent reports demonstrate that alcohol-induced protein acylation negatively impacts these processes. To identi...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-23 | PXD012089 | Pride
Ethanol metabolism Succinylation Mitochondira Acetylation Acylation 
GenomicsIntercellular nanotube-mediated mitochondrial transfer enhances T-cell metabolic fitness and antitumor efficacy
Intercellular nanotube-mediated mitochondrial transfer enhances T-cell metabolic fitness and antitumor efficacy
PRJNA954743 | ENA
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