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TranscriptomicsGenomic (in)stability of the breast tumor microenvironment
The breast tumor microenvironment plays an active role in tumorigenesis. Molecular alterations, including epigenetic modifications to DNA, and changes in RNA and protein expression have been identified in tumor-associated stroma; however, there is considerable debate as to whether the stroma is char...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-38071 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tumor microenvironment during breast cancer progression
To better understand the role of tumor microenvironment in breast cancer progression, we combined laser capture microdissection and microarray analysis to provide a comprehensive catalog of gene expression changes in both tumor and tumor-associated stroma. Experiment Overall Design: We used LCM to i...
ORGANISM(S): Homo sapiens 
2009-02-26 | E-GEOD-14548 | biostudies-arrayexpress
ModelsLiX2019 - macrophage polarization and tumor cell plasticity
This model is based on: Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment. Abstract: Tumor microenvironments contain multiple cell types interacting among one another via different signaling pathways. Furthermore, both ca...
2019-09-23 | MODEL1909230002 | BioModels
Immuno-oncology 
ModelsPro-inflammatory Tumor Microenvironment in Acute Lymphoblastic Leukemia
Lineage fate decisions of hematopoietic cells depend on intrinsic factors and extrinsic signals provided by the bone marrow microenvironment, where they reside. Abnormalities in composition and function of hematopoietic niches have been proposed as key contributors of acute lymphoblastic leukemia (A...
4942 | Cell Collective
TranscriptomicsRegulation of GLI underlies a role for BET bromodomains in pancreatic cancer growth and the tumor microenvironment
Pancreatic ductal adenocarcinoma (PDAC) is extraordinarily chemoresistant and the abundant stromal content of these tumors contributes to the ineffective treatment of this disease. While the genetic alterations of PDAC have been well characterized, the epigenetic pathways regulating PDAC remain, fo...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-55209 | biostudies-arrayexpress
TranscriptomicsExpression analysis of human ex vivo cultivated urothelial carcinoma samples transduced with a trivalent adenoviral vector (Im02) for activation of the immune tumor microenvironment.
The trivalent adenoviral vector Im02 encodes the cDNAs for human 4-1BBL, IL-12 and IL-2. This vector was designed to change the immune tumor microenvironment. In this study we investigated the immune stimulating effect of Im02 on human primary urothelial cancer specimens or normal urothelium by RNAS...
ORGANISM(S): Homo sapiens 
2020-06-18 | E-MTAB-7659 | biostudies-arrayexpress
ProteomicsThe murine metastatic microenvironment of experimental brain metastases in breast cancer differs by host age in vivo: A proteomic study.
Breast cancer in young patients is known to exhibit more aggressive biological behavior and is associated with a less favorable prognosis than the same disease in older patients, owing in part to an increased incidence of brain metastases, the mechanistic explanations behind which remain poorly unde...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-01-11 | PXD042346 | Pride
Laser microdissection Mouse model Brain metastases Breast cancer 
TranscriptomicsExpression analysis of human ex vivo cultivated urothelial carcinoma samples transduced with a trivalent adenoviral vector (Im02) for activation of the immune tumor microenvironment.
The trivalent adenoviral vector Im02 encodes the cDNAs for human 4-1BBL, IL-12 and IL-2. This vector was designed to change the immune tumor microenvironment. In this study we investigated the immune stimulating effect of Im02 on human primary urothelial cancer specimens or normal urothelium by micr...
ORGANISM(S): Homo sapiens 
2021-01-01 | E-MTAB-7623 | biostudies-arrayexpress
TranscriptomicsComparison of metastasis-inclined microenvironment (MIM) and metastasis-averse microenvironment (MAM) HCC patients
To determine the role of the hepatic microenvironment in HCC metastasis, we compared the gene expression profiles of 20 noncancerous surrounding hepatic tissues from two HCC patient groups, those with primary HCC together with venous metastasis which we termed a metastasis-inclined microenvironment ...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5093 | biostudies-arrayexpress
ModelsGanguli2018-immuno regulatory mechanisms in tumor microenvironment
This model describes the concept of Cancer Stem Cells(CSC) differentiation and tumor-immune interaction into a generic model that has been validated with known experimental data. Created by COPASI 4.24(Build197) Abstract: The tumor microenvironment comprising of the immune cells and cytokines acts a...
2024-09-02 | BIOMD0000000810 | BioModels
Immuno-oncology 
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