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MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
MetabolomicsA microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions

The blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity. We developed a physiologically relevant human neurovascular unit microfluidic chip (hNVU-on-a-chip) incorporating brain microvascular endoth...

2025-10-28 | MTBLS13230 | MetaboLights
TranscriptomicsMicrofluidic platform for monitoring Saccharomyces cerevisiae mutation accumulation assay
Saccharomyces cerevisiae wildtype (YPH) and ung1-deleted strains were cultivated in mutation accumulation experiments over several bottlenecks (0-50-100-150). Two different cutlure systems were used either (i) using random colony selection and plating on petri dish (classical); or (ii) a microfluidi...
ORGANISM(S): Saccharomyces cerevisiae S288C 
2021-08-01 | E-MTAB-10259 | biostudies-arrayexpress
MetabolomicsMetabolomics of murine embryos cultured in a microfluidic device and comparison with traditional microdrops culture
Not available
ORGANISM(S): Mus musculus 
ST001494 | MetabolomicsWorkbench
TranscriptomicsMicrofluidic single-cell whole-transcriptome sequencing
Single-cell whole-transcriptome analysis is a powerful tool for quantifying gene expression heterogeneity in populations of cells. Many techniques have, thus, been recently developed to perform transcriptome sequencing (RNA-Seq) on individual cells. To probe subtle biological variation between sampl...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-47835 | biostudies-arrayexpress
ProteomicsPepS: a microfluidic device to process whole blood at bedside for plasma proteomic analyses
Immunoassays have been used for decades in clinical laboratories to quantify proteins in serum/plasma samples. However, different limitations hinder their use in some cases. Mass spectrometry (MS)-based proteomics analysis has recently appeared as a promising option to assess panels of protein bioma...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD019403 | Pride
Human Microfluidic device Plasma Centrifugation Dda 
TranscriptomicsEffects of Escherichia coli global gene expression due to microfluidic processing
Investigation in bacterial transcriptomics is widely used to investigate gene regulation, bacterial susceptibility to antibiotics, host-pathogen interactions, and pathogenesis. Transcriptomics is crucially dependent on suitable methods to isolate and detect bacterial RNA. Microfluidic approaches off...
ORGANISM(S): Escherichia coli CFT073 
2016-04-01 | E-GEOD-68064 | biostudies-arrayexpress
TranscriptomicsmESCs cultured in microfluidic chambers take control of their fate by producing endogenous signals including LIF
mESCs cultured in microfluidic chambers secrete endogneous signals which accumulate to facilitate expression of pluripotency associated genes ES-D3 [D3] ATCC® CRL-1934™ mouse embryonic stem cells (strain: 129S2/SvPas) were culture in standard tissue culture wells or microfluidic chambers prior to...
ORGANISM(S): Mus musculus 
2015-12-18 | E-GEOD-75732 | biostudies-arrayexpress
ProteomicsAn exosome-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis
Exosomes, reflecting the live cellular state, hold promise for non-invasive disease detection. However, the significance of exosome cargos has been underestimated, particularly in the clinic, mainly due to the scarcity of exosome. Here, we present a "one-step" high-throughput microfluidic platform i...
ORGANISM(S): Homo Sapiens 
PXD053690 |
ProteomicsCombination of a microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement for the reliable production of high-quality organo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Sus scrofa domesticus (domestic pig) 
2021-06-02 | PXD025397 | Pride
Brain extracellular matrix Microfluidic device Organoid 
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