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ProteomicsA functional connection between the Microprocessor and a variant NEXT complex
In mammalian cells, primary miRNAs are cleaved at their hairpin structures by the Microprocessor complex, whose core is composed of DROSHA and DGCR8. Here, we show that 5’flanking regions, resulting from Microprocessor cleavage, are targeted by the RNA exosome in mouse embryonic stem cells (mESCs). ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-22 | PXD053925 | Pride
Zcchc8-dgcr8 interaction Rna structure Microprocessor Nuclear rna decay The next complex 
TranscriptomicsEndogenous shRNAs, siRNAs, and Other Microprocessor-independent, Dicer-dependent Small RNAs in Mouse ES Cells
Canonical microRNAs (miRNAs) require two processing steps: the first by the Microprocessor, a complex of DGCR8 and Drosha, and the second by Dicer. dgcr8delta/delta mouse embryonic stem cells (mESCs) have less severe phenotypes than dicer1delta/delta mESCs, suggesting a physiological role for Microp...
ORGANISM(S): Mus musculus 
2008-09-09 | E-GEOD-12521 | biostudies-arrayexpress
TranscriptomicsDGCR8 HITS-CLIP reveals novel functions for the Microprocessor (CLIP-seq)
The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 contains two double-stranded RNA binding motifs that recognize the RNA substrate, whereas Drosha functions as the endonuclease. We have used high-throughput sequencing of RNAs isolated by crosslinking immuno...
ORGANISM(S): Homo sapiens 
2012-07-15 | E-GEOD-39086 | biostudies-arrayexpress
GenomicsSingle cut products of Microprocessor on pri-miRNAs
Single cut products of Microprocessor on pri-miRNAs
PRJNA577891 | ENA
TranscriptomicsMutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors
Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor biology and find novel therapeutic leads for this subgroup of patients, we analyzed 58 blastemal-type Wilms tumors by exome and transcriptome sequ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60081 | biostudies-arrayexpress
GenomicsMolecular mechanism of mutations in Microprocessor causing Wilms tumors [miRNA]
Molecular mechanism of mutations in Microprocessor causing Wilms tumors [miRNA]
PRJNA1159117 | ENA
GenomicsMolecular mechanism of mutations in Microprocessor causing Wilms tumors [mRNA]
Molecular mechanism of mutations in Microprocessor causing Wilms tumors [mRNA]
PRJNA1159113 | ENA
GenomicsA functional connection between the Microprocessor and a variant NEXT complex
A functional connection between the Microprocessor and a variant NEXT complex
PRJNA1133631 | ENA
GenomicsMicroprocessor depends on hemin to recognize the apical loop of primary microRNA
Microprocessor depends on hemin to recognize the apical loop of primary microRNA
PRJNA436986 | ENA
UnknownThe Microprocessor controls the activity of mammalian retrotransposons.
Not available
S-EPMC3836241 | biostudies-literature
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